Caprine arthritis-encephalitis virus-infected goats can generate human immunodeficiency virus-gp120 cross-reactive antibodies(1).
Caprine arthritis-encephalitis virus-infected goats can generate human immunodeficiency virus-gp120 cross-reactive antibodies(1).
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感染山羊关节炎-脑炎病毒的山羊可产生人类免疫缺陷病毒-gp120 交叉反应抗体(1)。
DOI：
10.1016/s0042-6822(03)00523-3
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发表时间：
2003
期刊：
影响因子：
3.7
通讯作者：
McMillan,Minnie
中科院分区：
文献类型：
--
作者：
Louie,KatherineA;Dadgari,JosephM;DeBoer,BethanyM;Weisbuch,Hilary;Snow,PeterM;Cheevers,WilliamP;Douvas,Angeline;McMillan,Minnie
Lentiviruses display surprisingly disparate clinical manifestations in their specific hosts, share complex genetic structures, and exhibit extensive diversity, particularly in their envelope genes. The envelope protein, gp135, of caprine arthritis-encephalitis virus (CAEV) has minimal primary sequence homology to gp120, the envelope protein of human immunodeficiency virus (HIV). Nevertheless, they bear certain similarities in that they both possess five variable regions, both are heavily glycosylated, and both share short sequence motifs. We establish a further relationship and demonstrate that some goats, infected with CAEV, possess gp135-specific antibodies which cross-react with gp120 from several HIV strains, provided the protein is expressed in insect cells. We show that, although the cross-reactivity of these immunoglobulins depends on the level of glycosylation, nevertheless, some antibodies recognize the protein epitopes on gp120, at least some of which are linear in character. Further characterization of this unexpected cross-reaction will define its potential therapeutic utility.
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5.5
作者：
Kemp,RK;Knowles,DP;Perry,LL;McGuire,TC;Besser,TE;Cheevers,WP
通讯作者：
Cheevers,WP
影响因子：
3.7
作者：
KURODA, K;GEYER, H;KLENK, HD
通讯作者：
KLENK, HD
DOI：
10.1073/pnas.89.6.2213
发表时间：
1992-03-15
影响因子：
11.1
作者：
LEE, WR;SYU, WJ;LEE, TH
通讯作者：
LEE, TH