Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress.
Fructose increases risk for kidney stones: potential role in metabolic syndrome and heat stress.
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DOI：
10.1186/s12882-018-1105-0
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发表时间：
2018-11-08
期刊：
影响因子：
2.3
通讯作者：
Lanaspa MA
中科院分区：
文献类型：
--
作者：
Johnson RJ;Perez-Pozo SE;Lillo JL;Grases F;Schold JD;Kuwabara M;Sato Y;Hernando AA;Garcia G;Jensen T;Rivard C;Sanchez-Lozada LG;Roncal C;Lanaspa MA
Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones.我们假设果糖摄入会改变参与结石形成的血清和尿液成分。 We analyzed a previously published randomized controlled study that included 33 healthy male adults (40–65 years of age) who ingested 200 g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2 weeks.参与者在梅诺卡岛马特奥奥尔菲拉医院肾病科接受评估。评估了镁、钙、尿酸、磷、维生素 D 和完整 PTH 水平的血清水平变化。测量尿液镁、钙、尿酸、磷、柠檬酸盐、草酸盐、钠、钾以及尿液 pH 值。 Ingestion of fructose was associated with an increased serum level of uric acid (p < 0.001), a decrease in serum ionized calcium (p = 0.003) with a mild increase in PTH (p < 0.05) and a drop in urinary pH (p = 0.02), an increase in urine oxalate (p = 0.016) 和尿镁减少 (p = 0.003)。果糖似乎会增加尿路结石的形成，部分原因是通过影响尿酸盐代谢和尿液 pH 值，也通过影响草酸盐。 Fructose may be a contributing factor for the development of kidney stones in subjects with metabolic syndrome and those suffering from heat stress. ClinicalTrials.gov NCT00639756 2008 年 3 月 20 日。
Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum and urinary components involved in stone formation. We analyzed a previously published randomized controlled study that included 33 healthy male adults (40–65 years of age) who ingested 200 g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2 weeks. Participants were evaluated at the Unit of Nephrology of the Mateo Orfila Hospital in Menorca. Changes in serum levels of magnesium, calcium, uric acid, phosphorus, vitamin D, and intact PTH levels were evaluated. Urine magnesium, calcium, uric acid, phosphorus, citrate, oxalate, sodium, potassium, as well as urinary pH, were measured. Ingestion of fructose was associated with an increased serum level of uric acid (p < 0.001), a decrease in serum ionized calcium (p = 0.003) with a mild increase in PTH (p < 0.05) and a drop in urinary pH (p = 0.02), an increase in urine oxalate (p = 0.016) and decrease in urinary magnesium (p = 0.003). Fructose appears to increase urinary stone formation in part via effects on urate metabolism and urinary pH, and also via effects on oxalate. Fructose may be a contributing factor for the development of kidney stones in subjects with metabolic syndrome and those suffering from heat stress. ClinicalTrials.gov NCT00639756 March 20, 2008.
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影响因子：
4.5
作者：
Cox CL;Stanhope KL;Schwarz JM;Graham JL;Hatcher B;Griffen SC;Bremer AA;Berglund L;McGahan JP;Keim NL;Havel PJ
通讯作者：
Havel PJ
影响因子：
9.8
作者：
Chen, Wei;Roncal-Jimenez, Carlos;Lanaspa, Miguel;Smits, Gerard;Chonchol, Michel;Johnson, Richard J.;Jalal, Diana
通讯作者：
Jalal, Diana
影响因子：
13.6
作者：
Daudon, M;Traxer, O;Jungers, P
通讯作者：
Jungers, P
影响因子：
2.1
作者：
De, Shubha K.;Liu, Xiaobo;Monga, Manoj
通讯作者：
Monga, Manoj
影响因子：
--
作者：
Daudon, M;Lacour, B;Jungers, P
通讯作者：
Jungers, P