Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans.
Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans.
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DOI：
10.1186/1743-7075-9-68
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发表时间：
2012-07-24
影响因子：
4.5
通讯作者：
Havel PJ
中科院分区：
文献类型：
--
作者：
Cox CL;Stanhope KL;Schwarz JM;Graham JL;Hatcher B;Griffen SC;Bremer AA;Berglund L;McGahan JP;Keim NL;Havel PJ
在人类中检测果糖摄入对与代谢综合征发展相关的生物标记物的影响的前瞻性研究还缺乏。因此，我们研究了10周果糖或葡萄糖摄入对男性和女性血浆尿酸和RBP-4浓度以及肝酶(AST、ALT和GGT)活性的相对影响。作为ARM平行研究的一部分，年龄较大(40-72岁)、超重和肥胖的男性和女性受试者(体重指数25-35 kg/m2)摄入葡萄糖或果糖含糖饮料，提供10周所需能量的25%。分别在基线和干预10周后进行空腹和24小时采血，测定血尿酸、RBP-4浓度和肝酶活性。摄入果糖，但不摄入葡萄糖，可显著增加24小时尿酸水平(P <； 0.0001)和RBP-4浓度(P = 0.012)，以及血浆谷草转氨酶活性(P = 0.04)。两组患者的空腹血浆尿酸浓度均升高；然而，摄入果糖的受试者的反应更明显(糖的影响P = 0.002)。在果糖组中，男性受试者的RBP-4水平比女性的升高幅度更大(P = ，0.024)。这些发现表明，在10周内摄入果糖占能量需求的25%，与等卡路里的葡萄糖消耗相比，可能通过增加循环尿酸、GGT活性而促进代谢综合征的组成部分的发展，提示肝功能的改变和RBP-4的产生。
Prospective studies in humans examining the effects of fructose consumption on biological markers associated with the development of metabolic syndrome are lacking. Therefore we investigated the relative effects of 10 wks of fructose or glucose consumption on plasma uric acid and RBP-4 concentrations, as well as liver enzyme (AST, ALT, and GGT) activities in men and women. As part of a parallel arm study, older (age 40–72), overweight and obese male and female subjects (BMI 25–35 kg/m2) consumed glucose- or fructose-sweetened beverages providing 25% of energy requirements for 10 wks. Fasting and 24-h blood collections were performed at baseline and following 10 wks of intervention and plasma concentrations of uric acid, RBP-4 and liver enzyme activities were measured. Consumption of fructose, but not glucose, led to significant increases of 24-h uric acid profiles (P < 0.0001) and RBP-4 concentrations (P = 0.012), as well as plasma GGT activity (P = 0.04). Fasting plasma uric acid concentrations increased in both groups; however, the response was significantly greater in subjects consuming fructose (P = 0.002 for effect of sugar). Within the fructose group male subjects exhibited larger increases of RBP-4 levels than women (P = 0.024). These findings suggest that consumption of fructose at 25% of energy requirements for 10 wks, compared with isocaloric consumption of glucose, may contribute to the development of components of the metabolic syndrome by increasing circulating uric acid, GGT activity, suggesting alteration of hepatic function, and the production of RBP-4.
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影响因子：
8
作者：
Chang, Yu-Hung;Lin, Kun-Der;Shin, Shyi-Jang
通讯作者：
Shin, Shyi-Jang
影响因子：
29
作者：
Kloeting, Nora;Graham, Timothy E.;Kahn, Barbara B.
通讯作者：
Kahn, Barbara B.
影响因子：
158.5
作者：
Graham, Timothy E.;Yang, Qin;Kahn, Barbara B.
通讯作者：
Kahn, Barbara B.
影响因子：
7.1
作者：
Mayes, Peter A.
通讯作者：
Mayes, Peter A.
DOI：
10.1016/j.numecd.2007.05.002
发表时间：
2008-11-01
影响因子：
3.9
作者：
Bonora, Enzo;Capaldo, Brunella;Bonadonna, Riccardo C.
通讯作者：
Bonadonna, Riccardo C.