Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes.
Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes.
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DOI：
10.1021/bm201143c
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发表时间：
2012-01-09
影响因子：
6.2
通讯作者：
Turley EA
中科院分区：
文献类型：
--
作者：
Veiseh M;Breadner D;Ma J;Akentieva N;Savani RC;Harrison R;Mikilus D;Collis L;Gustafson S;Lee TY;Koropatnick J;Luyt LG;Bissell MJ;Turley EA
An increase in hyaluronan (HA) synthesis, cellular uptake, and metabolism occurs during the remodeling of tissue microenvironments following injury and during disease processes such as cancer. We hypothesized that multimodality HA-based probes selectively target and detectably accumulate at sites of high HA metabolism, thus providing a flexible imaging strategy for monitoring disease and repair processes. Kinetic analyses confirmed favorable available serum levels of the probe following intravenous (i.v.) or subcutaneous (s.c.) injection. Nuclear (technetium-HA, 99mTc-HA, and iodine-HA, 125I-HA), optical (fluorescent Texas Red-HA, TR-HA), and magnetic resonance (gadolinium-HA, Gd-HA) probes imaged liver (99mTc-HA), breast cancer cells/xenografts (TR-HA, Gd-HA), and vascular injury (125I-HA, TR-HA). Targeting of HA probes to these sites appeared to result from selective HA receptor-dependent localization. Our results suggest that HA-based probes, which do not require polysaccharide backbone modification to achieve favorable half-life and distribution, can detect elevated HA metabolism in homeostatic, injured, and diseased tissues.
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影响因子：
33.6
作者：
Jiang D;Liang J;Noble PW
通讯作者：
Noble PW
DOI：
10.2174/187152806779010936
发表时间：
2006-12-01
期刊：
Inflammation & Allergy Drug Targets
影响因子：
--
作者：
Cantor, Jerome O.;Nadkarni, Priya P.
通讯作者：
Nadkarni, Priya P.
影响因子：
3
作者：
GUSTAFSON, S;BJORKMAN, T;WESTLIN, JE
通讯作者：
WESTLIN, JE
影响因子：
5.3
作者：
Chajara, A;Raoudi, M;Levesque, H
通讯作者：
Levesque, H
影响因子：
1.7
作者：
Heublein, B;Evagorou, EG;Haverich, A
通讯作者：
Haverich, A