Hyaluronan as an immune regulator in human diseases.
Hyaluronan as an immune regulator in human diseases.
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DOI：
10.1152/physrev.00052.2009
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发表时间：
2011-01
影响因子：
33.6
通讯作者：
Noble PW
中科院分区：
文献类型：
--
作者：
Jiang D;Liang J;Noble PW
细胞外基质成分的积聚和周转是组织损伤的标志。片断的透明质酸通过损伤部位的各种免疫细胞刺激炎症基因的表达。透明质酸可与多种细胞类型上的多种细胞表面蛋白结合。透明质酸片段通过Toll样受体(TLR)4和TLR2以及CD44发出信号，刺激炎症细胞中的炎症基因。透明质酸也存在于上皮细胞的细胞表面，通过与这些实质细胞上的TLR2和TLR4相互作用来保护组织免受损伤。透明质酸和透明质酸结合蛋白通过调节炎症细胞募集、炎症细胞因子的释放和干细胞迁移来调节炎症、组织损伤和修复。本文就透明质酸作为免疫调节剂在人类疾病中的作用作一综述。
Accumulation and turnover of extracellular matrix components are the hallmarks of tissue injury. Fragmented hyaluronan stimulates the expression of inflammatory genes by a variety of immune cells at the injury site. Hyaluronan binds to a number of cell surface proteins on a variety of cell types. Hyaluronan fragments signal through both Toll-like receptor (TLR) 4 and TLR2 as well as CD44 to stimulate inflammatory genes in inflammatory cells. Hyaluronan is also present on the cell surface of epithelial cells and provides protection against tissue damage by interacting with TLR2 and TLR4 on these parenchymal cells. Hyaluronan and hyaluronan-binding proteins regulate inflammation, tissue injury and repair through regulating inflammatory cell recruitment, release of inflammatory cytokines, and stem cell migration. This review focuses on the role of hyaluronan as an immune regulator in human diseases.
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