Overexpression of high mobility group box 1 and 2 is associated with the progression and angiogenesis of human bladder carcinoma.
Overexpression of high mobility group box 1 and 2 is associated with the progression and angiogenesis of human bladder carcinoma.
复制标题
高迁移率组1和2的过表达与人膀胱癌的进展和血管生成有关。
DOI：
10.3892/ol.2012.1091
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发表时间：
2013-03
期刊：
影响因子：
2.9
通讯作者：
Ding Q
中科院分区：
文献类型：
--
作者：
Wang W;Jiang H;Zhu H;Zhang H;Gong J;Zhang L;Ding Q
在多种人类肿瘤类型中观察到高迁移率族蛋白 1 (HMGB1) 和 HMGB2 过度表达，并参与癌症进展和预后。然而，膀胱癌（BCa）中 HMGB1 和 HMGB2 表达的临床病理意义，特别是这些蛋白在血管生成中的参与，仍不清楚。本研究对 64 例 BCa 患者的 HMGB1 和 HMGB2 进行免疫组化和实时聚合酶链反应 (PCR) 检测，结果显示，与正常组织相比，BCa 组织中 HMGB1 和 HMGB2 过表达，且与肿瘤临床分期和病理分级相关。此外，血管内皮生长因子（VEGF）和微血管密度（MVD）计数的相关性分析表明，HMGB1和HMGB2的过表达也与血管生成相关。我们得出的结论是，HMGB 蛋白在膀胱癌的进展和血管生成中发挥着关键调节作用，并可作为潜在的诊断和治疗靶点。
High mobility group box 1 (HMGB1) and HMGB2 overexpression has been observed in several human tumor types, and is involved in cancer progression and prognosis. However, the clinicopathological significance of HMGB1 and HMGB2 expression in bladder carcinoma (BCa), particularly the involvement of these proteins in angiogenesis, remains unclear. In the present study, immunohistochemistry and real-time polymerase chain reaction (PCR) of HMGB1 and HMGB2 in 64 BCa patients revealed that HMGB1 and HMGB2 were overexpressed in BCa tissues compared with normal tissues, and were correlated with tumor clinical stage and pathological grade. In addition, correlation analysis of vascular endothelial growth factor (VEGF) and microvessel density (MVD) counts indicated that the overexpression of HMGB1 and HMGB2 was also correlated with angiogenesis. We conclude that HMGB proteins act as key regulators in the progression and angiogenesis of bladder carcinoma, and serve as potential diagnostic and therapeutic targets.
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影响因子：
8
作者：
van Beijnum, J. R.;Nowak-Sliwinska, P.;Griffioen, A. W.
通讯作者：
Griffioen, A. W.
影响因子：
4.3
作者：
Kostova, Nora;Zlateva, Stanislava;Pasheva, Evdokia
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影响因子：
6.6
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Ghoneim, Mohamed A.;Abdel-Latif, Mohamed;El-Baz, Mahmoud A.
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1
作者：
Ajili, Faouzia;Kacem, Monia;Boubaker, Samir
通讯作者：
Boubaker, Samir
影响因子：
2.4
作者：
Sharma, Ashok;Ray, Ruma;Rajeswari, Moganty R.
通讯作者：
Rajeswari, Moganty R.