DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets.
DNA methylation in diabetic retinopathy: pathogenetic role and potential therapeutic targets.
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DOI：
10.1186/s13578-022-00927-y
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发表时间：
2022-11-17
影响因子：
7.5
通讯作者：
Qiu Q
中科院分区：
文献类型：
--
作者：
Cai C;Meng C;He S;Gu C;Lhamo T;Draga D;Luo D;Qiu Q
糖尿病视网膜病变（DR）是糖尿病特有的神经血管并发症，是全球中年人视力丧失的主要原因，并且随着糖尿病发病率的增加，DR患者的数量将会增加。目前，其早期发现困难，治疗有限，晚期治疗效果不理想。 DR的发病机制复杂，涉及表观遗传修饰、氧化应激、炎症和新生血管形成。这些因素相互影响，共同促进DR的发展。 DNA甲基化是研究最多的表观遗传修饰，在基因表达调控和DR发生发展中发挥着关键作用。因此，本综述探讨了 DR 发生过程中 DNA 甲基化与其他复杂病理过程之间的关系。从 DNA 甲基化的角度来看，这篇综述提供了对潜在的诊断生物标志物、可预防的风险因素和新的治疗靶点的基本见解。 DNA 甲基化在 DR 中发挥着不可或缺的作用，并可能作为这种致盲疾病相对早期阶段的潜在生物标志物。与 DNA 甲基转移酶抑制剂联合使用可能是延迟甚至阻止患者进入晚期 DR 的潜在方法。
Diabetic retinopathy (DR), a specific neuron-vascular complication of diabetes, is a major cause of vision loss among middle-aged people worldwide, and the number of DR patients will increase with the increasing incidence of diabetes. At present, it is limited in difficult detection in the early stages, limited treatment and unsatisfactory treatment effects in the advanced stages. The pathogenesis of DR is complicated and involves epigenetic modifications, oxidative stress, inflammation and neovascularization. These factors influence each other and jointly promote the development of DR. DNA methylation is the most studied epigenetic modification, which has been a key role in the regulation of gene expression and the occurrence and development of DR. Thus, this review investigates the relationship between DNA methylation and other complex pathological processes in the development of DR. From the perspective of DNA methylation, this review provides basic insights into potential biomarkers for diagnosis, preventable risk factors, and novel targets for treatment. DNA methylation plays an indispensable role in DR and may serve as a prospective biomarker of this blinding disease in its relatively early stages. In combination with inhibitors of DNA methyltransferases can be a potential approach to delay or even prevent patients from getting advanced stages of DR.
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Dos Santos Nunes MK;Silva AS;de Queiroga Evangelista IW;Filho JM;Gomes CNAP;do Nascimento RAF;Luna RCP;de Carvalho Costa MJ;de Oliveira NFP;Persuhn DC
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影响因子：
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