Influence of microRNA on the maintenance of human iron metabolism.
Influence of microRNA on the maintenance of human iron metabolism.
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DOI：
10.3390/nu5072611
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发表时间：
2013-07-10
期刊：
影响因子：
5.9
通讯作者：
Clarke S
中科院分区：
文献类型：
--
作者：
Davis M;Clarke S
铁是一种必需营养素，对许多细胞功能至关重要，包括 DNA 合成、ATP 生成和细胞增殖。尽管铁是必需的，但过量的铁可能会导致自由基的产生，从而破坏细胞脂质、蛋白质和核酸。因此，维持和控制细胞铁稳态对于预防铁缺乏或铁中毒至关重要。细胞铁稳态的维持在很大程度上是由称为铁调节蛋白 (IRP) 的胞质 RNA 结合蛋白家族来协调的，其功能是转录后控制铁摄取、储存、运输和利用所需的 mRNA 编码蛋白的翻译和/或稳定性。最近，一类称为 microRNA (miRNA) 的小非编码 RNA 也与铁代谢的控制有关。迄今为止，miRNA已被证明可以转录后调节与铁获取（转铁蛋白受体和二价金属转运蛋白）、铁输出（铁转运蛋白）、铁储存（铁蛋白）、铁利用（ISCU）和协调全身铁稳态（HFE和血红蛋白）相关的基因的表达。鉴于 miRNA 的多样性和潜在 mRNA 靶标的数量，表征导致 miRNA 表达、生物发生和加工改变的因素将增强我们对细胞响应铁需求和/或铁可用性变化以控制细胞铁稳态的机制的理解。
Iron is an essential nutrient critical for many cellular functions including DNA synthesis, ATP generation, and cellular proliferation. Though essential, excessive iron may contribute to the generation of free radicals capable of damaging cellular lipids, proteins, and nucleic acids. As such, the maintenance and control of cellular iron homeostasis is critical to prevent either iron deficiency or iron toxicity conditions. The maintenance of cellular iron homeostasis is largely coordinated by a family of cytosolic RNA binding proteins known as Iron Regulatory Proteins (IRP) that function to post-transcriptionally control the translation and/or stability of mRNA encoding proteins required for iron uptake, storage, transport, and utilization. More recently, a class of small non-coding RNA known as microRNA (miRNA) has also been implicated in the control of iron metabolism. To date, miRNA have been demonstrated to post-transcriptionally regulate the expression of genes associated with iron acquisition (transferrin receptor and divalent metal transporter), iron export (ferroportin), iron storage (ferritin), iron utilization (ISCU), and coordination of systemic iron homeostasis (HFE and hemojevelin). Given the diversity of miRNA and number of potential mRNA targets, characterizing factors that contribute to alterations in miRNA expression, biogenesis, and processing will enhance our understanding of mechanisms by which cells respond to changes in iron demand and/or iron availability to control cellular iron homeostasis.
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影响因子：
29
作者：
Anderson SA;Nizzi CP;Chang YI;Deck KM;Schmidt PJ;Galy B;Damnernsawad A;Broman AT;Kendziorski C;Hentze MW;Fleming MD;Zhang J;Eisenstein RS
通讯作者：
Eisenstein RS
DOI：
10.1016/j.bbagrm.2012.06.001
发表时间：
2012-11
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4.7
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影响因子：
15.9
作者：
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影响因子：
14.9
作者：
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