Calorie restriction effects on circadian rhythms in gene expression are sex dependent.
Calorie restriction effects on circadian rhythms in gene expression are sex dependent.
复制标题
卡路里限制对基因表达中昼夜节律的影响是性别依赖性的。
DOI：
10.1038/s41598-017-09289-9
复制
发表时间：
2017-08-29
影响因子：
4.6
通讯作者：
Kondratov RV
中科院分区：
文献类型：
--
作者：
Astafev AA;Patel SA;Kondratov RV
生物钟基因表达的节律受到卡路里限制(CR)的影响，CR是一种已知的延长寿命的饮食范例。CR的许多生理效应在雄性和雌性之间是不同的；在这里，我们调查了动物的性别是否影响了CR引起的昼夜节律的变化。BMal1和三个周期(PER1、PER2和PER3)等生物钟基因在肝脏中的表达以及CR对这些基因表达的影响不受性别的影响，而Rev-Erbα、Ror Gamma和两个Cryptochome(Cry1和Cry2)基因的表达在雌雄之间存在差异。CR对Rev-Erbα、Ror-Gamma和Cry1基因表达的影响具有性别依赖性。在先前报道的受CR调控的Fmo3、Mup4、Serpina12和Cyp4a12基因中，Cyp4a14a的表达和作用具有性别特异性，而Cyp4a14a的表达不受性别影响。IGF信号在衰老和CR效应中起重要作用。IGF-1的表达受CR和生物钟的调节，我们发现IGF-1表达的节律具有性别二型性。我们的数据提供了分子证据，表明动物的性别是基因表达和对CR反应的昼夜节律的重要调节器。
The rhythms in the expression of circadian clock genes are affected by calorie restriction (CR), a dietary paradigm known to increase lifespan. Many physiological effects of CR differ between males and females; here we investigated if the sex of animals affects the CR induced changes in the circadian rhythms. The liver expression of some circadian clock genes such as Bmal1 and three Periods (Per1, Per2 and Per3) and the effect of CR on the expression of these genes were sex independent, while the expression of Rev-Erb alpha, Ror gamma and both Cryptochome (Cry1 and Cry2) genes was different between males and females. The effect of CR on Rev-Erb alpha, Ror gamma and Cry1 gene expression was sex dependent. The expression and the effects of CR were sex-specific for several genes previously reported to be regulated by CR: Fmo3, Mup4, Serpina12 and Cyp4a12, while the expression of Cyp4a14a was sex independent. IGF signaling plays an important role in aging and CR effects. Igf-1 expression is regulated by CR and by the circadian clock, we found that rhythms in Igf-1 expression have sexual dimorphism. Our data provide molecular evidence that the sex of animals is an important modulator of circadian rhythms in gene expression and their response to CR.
登录
查看更多内容
影响因子：
3.9
作者：
Falls, JG;Ryu, DY;Hodgson, E
通讯作者：
Hodgson, E
影响因子：
10.5
作者：
Kondratov, Roman V.;Kondratova, Anna A.;Antoch, Marina P.
通讯作者：
Antoch, Marina P.
影响因子：
29
作者：
Mitchell SJ;Madrigal-Matute J;Scheibye-Knudsen M;Fang E;Aon M;González-Reyes JA;Cortassa S;Kaushik S;Gonzalez-Freire M;Patel B;Wahl D;Ali A;Calvo-Rubio M;Burón MI;Guiterrez V;Ward TM;Palacios HH;Cai H;Frederick DW;Hine C;Broeskamp F;Habering L;Dawson J;Beasley TM;Wan J;Ikeno Y;Hubbard G;Becker KG;Zhang Y;Bohr VA;Longo DL;Navas P;Ferrucci L;Sinclair DA;Cohen P;Egan JM;Mitchell JR;Baur JA;Allison DB;Anson RM;Villalba JM;Madeo F;Cuervo AM;Pearson KJ;Ingram DK;Bernier M;de Cabo R
通讯作者：
de Cabo R
DOI：
10.18632/aging.100241
发表时间：
2010-12
期刊：
Aging
影响因子：
--
作者：
Dubrovsky YV;Samsa WE;Kondratov RV
通讯作者：
Kondratov RV
影响因子：
64.5
作者：
Nakahata Y;Kaluzova M;Grimaldi B;Sahar S;Hirayama J;Chen D;Guarente LP;Sassone-Corsi P
通讯作者：
Sassone-Corsi P