The Molecular Biology of Learning and Memory – Memory Phases and Signaling Cascades
The Molecular Biology of Learning and Memory – Memory Phases and Signaling Cascades
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学习和记忆的分子生物学——记忆阶段和信号级联
DOI：
10.1007/978-94-007-2099-2_31
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发表时间：
2012
影响因子：
4.7
通讯作者：
U. Müller
中科院分区：
文献类型：
--
作者：
U. Müller
在软体动物、昆虫、鸟类和哺乳动物等多种多样的物种中，记忆是高度动态的，涵盖了从几秒钟到一生的各个阶段。在蜜蜂和其他物种中，不同记忆阶段的诱导取决于训练试验的数量和连续性等参数。采用开发的技术来监测和操纵信号级联的活动在完整的蜜蜂，训练参数可以链接到时间调制的信号级联，有助于不同的记忆阶段。该分析揭示了触角叶（AL）和蘑菇体（MB）中的信号事件的动态网络，这些信号事件是两个定义方面所需的，即诱导和维持不同的记忆阶段。
In species as diverse as mollusks, insects, birds, and mammals memories are highly dynamic and cover phases from seconds to a lifetime. In honey bees as in other species, the induction of distinct memory phases depends on parameters like the number and succession of the training trials. Employing techniques developed to monitor and manipulate the activity of signaling cascades in intact honey bees, training parameters could be linked to temporal modulations of signaling cascades that contribute to distinct memory phases. This analysis uncovered a dynamic network of signaling events in the antennal lobes (ALs) and the mushroom bodies (MBs) that are required for defined aspects of both, the induction and the maintenance of distinct memory phases.
影响因子：
56.9
作者：
NGUYEN, PV;ABEL, T;KANDEL, ER
通讯作者：
KANDEL, ER