The genetic variant on chromosome 10p14 is associated with risk of colorectal cancer: results from a case-control study and a meta-analysis.
The genetic variant on chromosome 10p14 is associated with risk of colorectal cancer: results from a case-control study and a meta-analysis.
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染色体 10p14 的遗传变异与结直肠癌的风险相关：病例对照研究和荟萃分析的结果
DOI：
10.1371/journal.pone.0064310
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Nie S
中科院分区：
文献类型：
--
作者：
Qin Q;Liu L;Zhong R;Zou L;Yin J;Zhu B;Cao B;Chen W;Chen J;Li X;Li T;Lu X;Lou J;Ke J;Wei S;Miao X;Nie S
首先确定出一个共同的核苷酸多态性（SNP），RS10795668，该核苷酸（SNP）在10p14处被确定为与大型结合研究（GWAS）在2008年的重复和重复后，与结直肠癌（CRC）的风险显着相关。研究产生了矛盾的结果。
我们对中国人群进行了470例病例和475个对照的病例对照研究，然后进行了荟萃分析，整合了当前的研究和9个出版物，以评估研究和CRC风险之间的关联。通过基于χ2的Q统计测试和EGGER测试。
在病例对照研究中，观察到SNP和CRC风险之间的显着关联，每位或0.71（95％CI：0.54-0.94，p = 0.017）。在欧洲人口中的相关性，与每位贵族或0.91（95％CI：0.89-0.93，苯二世> 0.05）和0.86（95％CI：0.78-0.96，P异质性）的关联<0.05）在亚洲人群中，灵敏度分析和出版偏见评估表明结果的稳定性和可靠性。
我们的病例对照研究和随后的荟萃分析的结果证实了RS10795668与CRC风险的显着关联。
Background A common single nucleotide polymorphism (SNP), rs10795668, located at 10p14, was first identified to be significantly associated with risk of colorectal cancer (CRC) by a genome-wide association study (GWAS) in 2008; however, another GWAS and following replication studies yielded conflicting results. Methods We conducted a case-control study of 470 cases and 475 controls in a Chinese population and then performed a meta-analysis, integrating the current study and 9 publications to evaluate the association between rs10795668 and CRC risk. Heterogeneity among studies and publication bias were assessed by the χ2-based Q statistic test and Egger's test, respectively. Results In the case-control study, significant association between the SNP and CRC risk was observed, with per-A-allele OR of 0.71 (95%CI: 0.54–0.94, P = 0.017). The following meta-analysis further confirmed the significant association, with per-A-allele OR of 0.91 (95%CI: 0.89–0.93, Pheterogeneity>0.05) in European population and 0.86 (95%CI: 0.78–0.96, P heterogeneity <0.05) in Asian population. Besides, sensitivity analyses and publication bias assessment indicated the robust stability and reliability of the results. Conclusions Results from our case-control study and the followed meta-analysis confirmed the significant association of rs10795668 with CRC risk.
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影响因子：
11.2
作者：
Hutter, Carolyn M.;Chang-Claude, Jenny;Peters, Ulrike
通讯作者：
Peters, Ulrike
影响因子：
29.4
作者：
Kupfer SS;Anderson JR;Hooker S;Skol A;Kittles RA;Keku TO;Sandler RS;Ellis NA
通讯作者：
Ellis NA
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
30.8
作者：
Jaeger, Emma;Webb, Emily;Tomlinson, Ian
通讯作者：
Tomlinson, Ian
影响因子：
30.8
作者：
Broderick, Peter;Carvajal-Carmona, Luis;Houlston, Richard S.
通讯作者：
Houlston, Richard S.