Association of immunoexpression of the galectins-3 and -7 with histopathological and clinical parameters in oral squamous cell carcinoma in young patients
Association of immunoexpression of the galectins-3 and -7 with histopathological and clinical parameters in oral squamous cell carcinoma in young patients
复制标题
年轻患者口腔鳞状细胞癌中半乳糖凝集素-3和-7的免疫表达与组织病理学和临床参数的关系
DOI：
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发表时间：
2014
影响因子：
2.6
通讯作者：
P. Alves
中科院分区：
文献类型：
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作者：
J. A. Mesquita;L. Queiroz;É. J. Silveira;M. GORDÓN;G. Godoy;C. Nonaka;P. Alves
近年来，口腔鳞状细胞癌（OSCC）在45岁以下人群中的发病率不断上升。年轻患者的口腔鳞状细胞癌在生物学行为和预后方面与老年患者相比更具侵袭性。本研究的目的是分析32例年轻人口腔鳞癌中半乳糖凝集素-3和-7的免疫组化表达，并将其表达与临床和形态学参数相关联。样本中的所有OSCC病例均在2002年至2012年期间在巴西帕拉伊巴的肿瘤转诊医院诊断。从患者记录中获得临床数据。使用由布雷恩等人（J Pathol 166：375-381，1992）和世界卫生组织（In：Pathology and genetics of head and neck tumors：Word Health Organization classification of tumors，2005）提出的组织学恶性肿瘤分级系统进行形态学分析。使用抗半乳糖凝集素-3和-7抗体通过链霉亲和素-生物素技术进行免疫组织化学。结果通过卡方检验和Fisher精确检验进行统计学分析（p < 0.05）。在65.6%的分析病例中观察到半乳糖凝集素-3的免疫表达，但与研究的任何变量（临床分期;组织学恶性肿瘤分级系统）均无显著相关性。在96.9%的病例中观察到半乳糖凝集素-7的免疫表达，并且与组织学恶性分级系统显著相关（p < 0.05）。总之，结果表明，半乳糖凝集素-7作为生物学行为和肿瘤进展的标志物在年轻患者的口腔鳞癌的使用。
An increasing incidence of oral squamous cell carcinoma (OSCC) in individuals younger than 45 years has been observed in recent years. OSCC in younger patients differs in terms of biological behavior and prognosis with the disease being more aggressive than in older patients. The aim of this study was to analyze the immunohistochemical expression of galectins-3 and -7 in 32 cases of OSCC in young patients and to correlate this expression with clinical and morphological parameters. All cases of OSCC of the sample were diagnosed at oncology referral hospitals in Paraíba, Brazil, between 2002 and 2012. Clinical data were obtained from the patient records. Histological malignancy grading systems proposed by Bryne et al. (J Pathol 166:375–381, 1992) and the World Health Organization (In: Pathology and genetics of head and neck tumours: Word Health Organization classification of tumours, 2005) were used for morphological analysis. Immunohistochemistry was performed by the streptavidin–biotin technique using anti-galectin-3 and -7 antibodies. The results were analyzed statistically by the Chi-squared and Fisher exact tests (p < 0.05). Immunoexpression of galectin-3 was observed in 65.6 % of the cases analyzed, but showed no significant association with any of the variables studied (clinical staging; histological malignancy grading systems). Immunoexpression of galectin-7 was observed in 96.9 % of cases and was significantly associated with histological malignancy grading systems (p < 0.05). In conclusion, the results suggest the use of galectin-7 as marker of biological behavior and tumor progression in OSCC in young patients.
DOI：
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发表时间：
2000-12
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
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作者：
Y. Honjo;Hidenori Inohara;Shiro Akahani;T. Yoshii;Y. Takenaka;Junpei Yoshida;K. Hattori;Y. Tomiyama-Y.-To
通讯作者：
Y. Honjo;Hidenori Inohara;Shiro Akahani;T. Yoshii;Y. Takenaka;Junpei Yoshida;K. Hattori;Y. Tomiyama-Y.-To