Measurement and visualization of mass transport for the flowing atmospheric pressure afterglow (FAPA) ambient mass-spectrometry source.
Measurement and visualization of mass transport for the flowing atmospheric pressure afterglow (FAPA) ambient mass-spectrometry source.
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DOI：
10.1007/s13361-014-0843-x
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发表时间：
2014-05
影响因子：
3.2
通讯作者：
Hieftje, Gary M.
中科院分区：
文献类型：
--
作者：
Pfeuffer, Kevin P.;Ray, Steven J.;Hieftje, Gary M.
环境解吸电离质谱（ADI-MS）在过去的九年中已经发展成为一个重要的分析领域。在环境条件下分析样品的能力，同时保持质谱的灵敏度和特异性，导致了许多应用和该领域的普及相应的跳跃。尽管ADI-MS具有很大的潜力，但在离子识别和定量方面仍然存在问题。离子识别的困难可以通过改进的仪器来解决，包括用于分析物识别的精确质量或MS/MS能力。更困难的问题包括由于采样过程的环境性质而导致的量化。为了表征和改善样品挥发、电离和引入质谱仪界面，需要一种将质量传输可视化到质谱仪中的方法。纹影成像是一种成熟的技术，其使折射率的微小变化可见。在这里，纹影成像用于可视化氦流从基于等离子体的ADI-MS源进入质谱仪，同时记录离子信号。熔点毛细管和传输模式（不锈钢网）引入的最佳样品位置被发现是附近（1毫米内）的质谱仪入口。此外，采样表面的方向起着重要的作用。更有效的质量传输导致分析物沉积物直接面向MS入口。还检查了不同的表面（载玻片和粗糙表面）;发现两者的最佳位置都在MS入口的正下方。
Ambient desorption/ionization mass spectrometry (ADI-MS) has developed into an important analytical field over the last nine years. The ability to analyze samples under ambient conditions while retaining the sensitivity and specificity of mass spectrometry has led to numerous applications and a corresponding jump in the popularity of this field. Despite the great potential of ADI-MS, problems remain in the areas of ion identification and quantification. Difficulties with ion identification can be solved through modified instrumentation, including accurate-mass or MS/MS capabilities for analyte identification. More difficult problems include quantification due to the ambient nature of the sampling process. To characterize and improve sample volatilization, ionization, and introduction into the mass-spectrometer interface, a method of visualizing mass transport into the mass spectrometer is needed. Schlieren imaging is a well-established technique that renders small changes in refractive index visible. Here, schlieren imaging was used to visualize helium flow from a plasma-based ADI-MS source into a mass spectrometer while ion signals were recorded. Optimal sample positions for melting-point capillary and transmission-mode (stainless steel mesh) introduction were found to be near (within 1 mm of) the mass spectrometer inlet. Additionally, the orientation of the sampled surface plays a significant role. More efficient mass transport resulted for analyte deposits directly facing the MS inlet. Different surfaces (glass slide and rough surface) were also examined; for both it was found that the optimal position is immediately beneath the MS inlet.
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DOI：
10.1007/s13361-011-0211-z
发表时间：
2011-11-01
影响因子：
3.2
作者：
Poehler, Thorsten;Kunte, Robert;Benter, Thorsten
通讯作者：
Benter, Thorsten
DOI：
10.1016/j.jasms.2008.12.020
发表时间：
2009-05-01
影响因子：
3.2
作者：
Shelley, Jacob T.;Wiley, Joshua S.;Hieftje, Gary M.
通讯作者：
Hieftje, Gary M.
影响因子：
7.4
作者：
Cody, RB;Laramée, JA;Durst, HD
通讯作者：
Durst, HD
影响因子：
7.4
作者：
Albert, Anastasia;Engelhard, Carsten
通讯作者：
Engelhard, Carsten
影响因子：
7.4
作者：
Shelley, Jacob T.;Wiley, Joshua S.;Hieftje, Gary M.
通讯作者：
Hieftje, Gary M.