Tetrahydrocurcumin protects against cadmium-induced hypertension, raised arterial stiffness and vascular remodeling in mice.
Tetrahydrocurcumin protects against cadmium-induced hypertension, raised arterial stiffness and vascular remodeling in mice.
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四氢瓜蛋白可预防小鼠镉诱导的高血压，升高动脉刚度和血管重塑。
DOI：
10.1371/journal.pone.0114908
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Greenwald SE
中科院分区：
文献类型：
--
作者：
Sangartit W;Kukongviriyapan U;Donpunha W;Pakdeechote P;Kukongviriyapan V;Surawattanawan P;Greenwald SE
镉 (Cd) 是一种非必需重金属，会对各种组织造成氧化损伤，并与高血压有关。四氢姜黄素 (THU) 是姜黄素的主要代谢产物，已被证明是一种抗氧化剂、抗糖尿病、抗高血压和抗炎剂。在这项研究中，我们研究了 THU 对小鼠镉诱导的高血压、动脉僵硬度增加和血管重塑的保护作用。雄性 ICR 小鼠通过饮用水接受 CdCl2 (100 mg/l) 治疗 8 周。 THU 以 50 或 100 mg/kg/天的剂量与 Cd 治疗同时胃内施用。 CdCl2 的施用显着增加了动脉血压，减弱了血管对血管活性药物的反应，增加了主动脉僵硬度，并通过增加主动脉内壁中平滑肌细胞和胶原沉积的数量、减少弹性蛋白以及增加基质金属蛋白酶 (MMP)-2 和 MMP-9 水平诱导肥厚的主动脉壁重塑。补充 THU 可显着降低血压，改善血管反应性，并逆转主动脉的结构和机械变化，包括胶原蛋白和弹性蛋白沉积。镉治疗不良反应的减少与 eNOS 蛋白表达上调和 iNOS 蛋白表达下调、硝酸盐/亚硝酸盐水平增加、氧化应激减轻和抗氧化谷胱甘肽增强有关。此外，THU还减少了血液和组织中镉的积累。我们的研究结果表明，THU 通过增强 NO 生物利用度、减轻氧化应激、改善血管重塑和减少其他组织中的 Cd 积累，改善镉引起的高血压、血管功能障碍和动脉僵硬度。 THU 在缓解与镉暴露相关的血管改变方面具有有益作用。
Cadmium (Cd) is a nonessential heavy metal, causing oxidative damage to various tissues and associated with hypertension. Tetrahydrocurcumin (THU), a major metabolite of curcumin, has been demonstrated to be an antioxidant, anti-diabetic, anti-hypertensive and anti-inflammatory agent. In this study, we investigated the protective effect of THU against Cd-induced hypertension, raised arterial stiffness and vascular remodeling in mice. Male ICR mice received CdCl2 (100 mg/l) via drinking water for 8 weeks. THU was administered intragastrically at dose of 50 or 100 mg/kg/day concurrently with Cd treatment. Administration of CdCl2 significantly increased arterial blood pressure, blunted vascular responses to vasoactive agents, increased aortic stiffness, and induced hypertrophic aortic wall remodeling by increasing number of smooth muscle cells and collagen deposition, decreasing elastin, and increasing matrix metalloproteinase (MMP)-2 and MMP-9 levels in the aortic medial wall. Supplementation with THU significantly decreased blood pressure, improved vascular responsiveness, and reversed the structural and mechanical alterations of the aortas, including collagen and elastin deposition. The reduction on the adverse response of Cd treatment was associated with upregulated eNOS and downregulated iNOS protein expressions, increased nitrate/nitrite level, alleviated oxidative stress and enhanced antioxidant glutathione. Moreover, THU also reduced the accumulation of Cd in the blood and tissues. Our results suggest that THU ameliorates cadmium-induced hypertension, vascular dysfunction, and arterial stiffness in mice through enhancing NO bioavailability, attenuating oxidative stress, improving vascular remodeling and decreasing Cd accumulation in other tissues. THU has a beneficial effect in moderating the vascular alterations associated with Cd exposure.
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DOI：
10.1186/1476-9255-6-19
发表时间：
2009-06-12
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Kundu S;Sengupta S;Chatterjee S;Mitra S;Bhattacharyya A
通讯作者：
Bhattacharyya A
影响因子：
37.8
作者：
Förstermann, U;Münzel, T
通讯作者：
Münzel, T
影响因子：
4.5
作者：
Eybl, Vladislav;Kotyzova, Dana;Koutensky, Jaroslav
通讯作者：
Koutensky, Jaroslav
影响因子：
--
作者：
Lambertucci, Rafael Herling;Leandro, Carol Gals;Pithon-Curi, Tania Cristina
通讯作者：
Pithon-Curi, Tania Cristina
影响因子：
2.9
作者：
Alissa EM;Ferns GA
通讯作者：
Ferns GA