Calibration of T(2) oximetry MRI for subjects with sickle cell disease.
Calibration of T(2) oximetry MRI for subjects with sickle cell disease.
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DOI：
10.1002/mrm.28757
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发表时间：
2021-08
影响因子：
3.3
通讯作者：
Wood JC
中科院分区：
文献类型：
--
作者：
Bush A;Vu C;Choi S;Borzage M;Miao X;Li W;Qin Q;Nederveen AJ;Coates TD;Wood JC
脑T2血氧测定是一种测量血液T2和脑静脉氧合的非侵入性成像方法。测量的T2值转换为血氧测定估计使用仔细验证和潜在的疾病特异性校准。在镰状细胞病中，红细胞具有异常的细胞形状和膜特性，其以临床上有意义的方式改变T2血氧测定校准关系。先前由两个独立小组进行的体外工作建立了潜在竞争的校准模型。本研究分析了这两项研究的汇总数据集，以建立统一且更稳健的镰刀特异性校准，作为该领域的参考标准。尽管与先前的模型相比，组合校准没有表现出统计学优效性，但与血气血氧饱和度相比，校准是无偏的，并且在患有镰状细胞病的非输血受试者中产生的一致性限度为（-10.1%，11.6%）。在输血患者中，本研究提出了一种基于个体血红蛋白S百分比的简单校正方法，与之前未校正的镰刀校准相比，该方法证明了饱和度测量的偏倚降低。组合校准基于更大范围的红细胞压积，为红细胞压积依赖性模型参数提供更大的置信度，并对两个研究中心的血气一氧化碳血氧测定测量值进行无偏估计。此外，这项工作还证明了需要在高输血镰状细胞病患者的T2血氧测定测量中校正输血，并提出了一种基于患者特异性血红蛋白S浓度的校正方法。
Cerebral T2 oximetry is a non-invasive imaging method to measure blood T2 and cerebral venous oxygenation. Measured T2 values are converted to oximetry estimates using carefully validated and potentially disease-specific calibrations. In sickle cell disease, red blood cells have abnormal cell shape and membrane properties that alter T2 oximetry calibration relationships in clinically meaningful ways. Previous in vitro works by two independent groups established potentially competing calibration models. This study analyzed pooled datasets from these two studies to establish a unified and more robust sickle-specific calibration to serve as a reference standard in the field. Even though the combined calibration did not demonstrate statistical superiority compared to previous models, the calibration was unbiased compared to blood-gas co-oximetry and yielded limits of agreement of (−10.1%, 11.6%) in non-transfused subjects with sickle cell disease. In transfused patients, this study proposed a simple correction method based on individual hemoglobin S percentage that demonstrated reduced bias in saturation measurement compared to previous uncorrected sickle calibrations. The combined calibration is based on a larger range of hematocrit, providing greater confidence in the hematocrit-dependent model parameters, and yielded unbiased estimates to blood-gas co-oximetry measurements from both sites. Additionally, this work also demonstrated the need to correct for transfusion in T2 oximetry measurements for hyper-transfused sickle cell disease patients and proposes a correction method based on patient-specific hemoglobin S concentration.
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影响因子：
--
作者：
Eaton, W A;Hofrichter, J
通讯作者：
Hofrichter, J
影响因子：
3.3
作者：
Bush AM;Coates TD;Wood JC
通讯作者：
Wood JC
DOI：
10.1002/jmri.1880010303
发表时间：
1991-05-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
WRIGHT, GA;HU, BS;MACOVSKI, A
通讯作者：
MACOVSKI, A
影响因子：
2.5
作者：
Hsieh CY;Cheng YN;Xie H;Haacke EM;Neelavalli J
通讯作者：
Neelavalli J
影响因子：
3.3
作者：
Chen, Jean J.;Pike, G. Bruce
通讯作者：
Pike, G. Bruce