Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions.
Elastic fibers in orthopedics: Form and function in tendons and ligaments, clinical implications, and future directions.
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DOI：
10.1002/jor.24695
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Lake SP
中科院分区：
文献类型：
--
作者：
Hill JR;Eekhoff JD;Brophy RH;Lake SP
弹性纤维是结缔组织细胞外基质的重要组成部分。弹性纤维疾病的临床管理和科学研究的重点都集中在心血管表现上，因为它们对发病率和死亡率有显著影响。因此，目前对这些患者经历的骨科疾病的了解有限。更微妙的弹性纤维异常的肌肉骨骼影响，无论是由于等位基因变异或年龄相关的组织变性，也没有得到很好的理解。最近的进展已经开始揭示肌腱和韧带生物力学的弹性纤维缺乏的影响，未来的研究必须进一步阐明这些组织中的弹性纤维的作用机制。识别弹性纤维中基于群体的遗传变异也是必不可少的。米诺地尔的管理，用微小RNA分子调节蛋白质表达，和重组弹性纤维前体的直接注射已被证明是有希望的治疗干预，但需要进一步的工作之前，骨科临床应用的考虑。本文综述了弹性纤维在肌肉骨骼组织中的作用，总结了目前弹性纤维异常的骨科表现的知识，并确定了未来的研究和临床应用的机会。
Elastic fibers are an essential component of the extracellular matrix of connective tissues. The focus of both clinical management and scientific investigation of elastic fiber disorders has centered on the cardiovascular manifestations due to their significant impact on morbidity and mortality. As such, current understanding of the orthopaedic conditions experienced by these patients is limited. The musculoskeletal implications of more subtle elastic fiber abnormalities, whether due to allelic variants or age-related tissue degeneration, are also not well understood. Recent advances have begun to uncover the effects of elastic fiber deficiency on tendon and ligament biomechanics; future research must further elucidate mechanisms governing the role of elastic fibers in these tissues. Identification of population-based genetic variations in elastic fibers will also be essential. Minoxidil administration, modulation of protein expression with micro-RNA molecules, and direct injection of recombinant elastic fiber precursors have demonstrated promise for therapeutic intervention, but further work is required prior to consideration for orthopaedic clinical application. This review provides an overview of the role of elastic fibers in musculoskeletal tissue, summarizes current knowledge of the orthopaedic manifestations of elastic fiber abnormalities, and identifies opportunities for future investigation and clinical application.
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影响因子：
--
作者：
Castagna A;Cesari E;Gigante A;Di Matteo B;Garofalo R;Porcellini G
通讯作者：
Porcellini G
影响因子：
2.4
作者：
Collinge, Richard;Simmonds, Jane V.
通讯作者：
Simmonds, Jane V.
影响因子：
15.9
作者：
Cook, Jason R.;Carta, Luca;Ramirez, Francesco
通讯作者：
Ramirez, Francesco
影响因子：
4.8
作者：
Bax, DV;Bernard, SE;Kielty, CM
通讯作者：
Kielty, CM
DOI：
10.1115/1.4036602
发表时间：
2017-07-01
影响因子：
1.7
作者：
Fang, Fei;Lake, Spencer P.
通讯作者：
Lake, Spencer P.