The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention.
The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention.
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DOI：
10.1155/2013/369172
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发表时间：
2013
影响因子：
--
通讯作者：
Muller WJ
中科院分区：
文献类型：
--
作者：
Gantt S;Muller WJ
单纯疱疹病毒1型和2型（HSV-1和HSV-2）感染世界上大部分人口。感染是终身的，可引起周期性的粘膜皮肤症状，但它很少在免疫功能正常的儿童和成人中引起危及生命的疾病。然而，当HSV感染发生在新生儿期时，病毒复制控制不佳，即使采用最佳抗病毒治疗，也有很大比例的婴儿死亡或发生残疾。新生儿的免疫系统与年龄较大的儿童和成人的免疫系统之间的具体差异越来越多地得到阐明，这些差异易患严重感染，并反映了从胎儿到产后的过渡。对不同年龄的健康个体、原发性或获得性免疫缺陷个体和动物模型的研究有助于我们了解控制HSV感染的机制以及这些机制在新生儿期如何受损。本文概述了我们目前对HSV感染的先天性和适应性免疫的理解，婴儿早期可能导致新生儿HSV感染表现的免疫学差异，以及干预措施增强新生儿对HSV疾病的免疫保护的潜力。
Herpes simplex viruses types 1 and 2 (HSV-1 and HSV-2) infect a large proportion of the world's population. Infection is life-long and can cause periodic mucocutaneous symptoms, but it only rarely causes life-threatening disease among immunocompetent children and adults. However, when HSV infection occurs during the neonatal period, viral replication is poorly controlled and a large proportion of infants die or develop disability even with optimal antiviral therapy. Increasingly, specific differences are being elucidated between the immune system of newborns and those of older children and adults, which predispose to severe infections and reflect the transition from fetal to postnatal life. Studies in healthy individuals of different ages, individuals with primary or acquired immunodeficiencies, and animal models have contributed to our understanding of the mechanisms that control HSV infection and how these may be impaired during the neonatal period. This paper outlines our current understanding of innate and adaptive immunity to HSV infection, immunologic differences in early infancy that may account for the manifestations of neonatal HSV infection, and the potential of interventions to augment neonatal immune protection against HSV disease.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
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发表时间：
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期刊：
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影响因子：
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作者：
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作者：
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