Trends in breast cancer mortality by stage at diagnosis among young women in the United States.

Trends in breast cancer mortality by stage at diagnosis among young women in the United States.
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DOI:
10.1002/cncr.31638
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发表时间:
2018-09-01
期刊:
影响因子:
6.2
通讯作者:
Berenson AB
Berenson AB
中科院分区:
医学1区
文献类型:
--
作者:
Guo F;Kuo YF;Shih YCT;Giordano SH;Berenson AB

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评估基本上未受乳腺癌筛查影响的年轻女性的乳腺癌存活趋势,将提供有关过去几十年乳腺癌癌症治疗有效性改进的重要信息。该研究队列包括1975年至2015年期间来自SEER项目9个登记区域的20至39岁被诊断患有乳腺癌的女性。我们评估了年轻女性乳腺癌发病率和生存率的趋势。在20-39岁的女性中,乳腺癌发病率从1975年的24.6 / 10万增加到2015年的31.7 / 10万(APC 0.5, 95% CI 0.4-0.6)。在女性乳腺癌患者中,5年乳腺癌特异性生存率从1975-1979年的74.0%显著增加到2010-2015年的88.5%(2010-2015年乳腺癌死亡风险比vs 1975-1979年0.37,95% CI 0.32-0.41)。癌症特异性生存率的增加在2005年达到平台期,但在转移性乳腺癌中,它在2005年之后继续增加,从2005 - 2009年的45.6%增加到2010-2015年的56.5%(2010-2015年死于乳腺癌的风险比,2010-2015年vs 2005 - 2009年0.74,95% CI 0.60-0.92)。在20-29岁和30-39岁女性的5年总生存率中也观察到类似的模式。从1975年到2015年,乳腺癌治疗的有效性在总体和癌症特异性生存方面有了实质性的改善。然而,改善似乎在2005年之后达到了一个平台,除了转移性乳腺癌,其生存率在1975-2015年期间持续改善。
Assessing trends in breast cancer survival among young women who are largely unaffected by breast cancer screening will provide important information regarding improvements in the effectiveness of cancer care for breast cancer in the last few decades. The study cohort consisted of women diagnosed with breast cancer between 20 and 39 years of age from the SEER Program’s 9 registry areas from 1975 to 2015. We assessed trends in breast cancer incidence rate and survival among young women. Among women 20–39 years old, breast cancer incidence increased from 24.6 per 100,000 in 1975 to 31.7 per 100,000 in 2015 (APC 0.5, 95% CI 0.4–0.6). Among female breast cancer patients, 5-year breast-cancer-specific survival increased significantly from 74.0% in 1975–1979 to 88.5% in 2010–2015 (hazard ratio for dying from breast cancer, 2010–2015 vs 1975–1979 0.37, 95% CI 0.32–0.41). The increase in cancer-specific survival reached a plateau in 2005, but in metastatic breast cancer, it continued to increase after 2005, from 45.6% in 2005–2009 to 56.5% in 2010–2015 (hazard ratio for dying from breast cancer, 2010–2015 vs 2005–2009 0.74, 95% CI 0.60–0.92). Similar patterns were also observed for 5-year overall survival and among women 20–29 and 30–39 years old. There were substantial improvements in the effectiveness of breast cancer treatment on overall and cancer-specific survival from 1975–2015. However, improvements appeared to have reached a plateau after 2005, except for metastatic breast cancer in which survival continued to improve throughout the 1975–2015 period.
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