A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer.
A Beam-Specific Optimization Target Volume for Stereotactic Proton Pencil Beam Scanning Therapy for Locally Advanced Pancreatic Cancer.
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DOI：
10.1016/j.adro.2021.100757
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发表时间：
2021-11
影响因子：
2.3
通讯作者：
Ding K
中科院分区：
文献类型：
--
作者：
Han D;Hooshangnejad H;Chen CC;Ding K
我们研究了两种基于边缘的优化靶区(OTV)方案，包括各向同性扩展(2 Mm)和射束特定的OTV，以解决胰腺立体定向铅笔束扫描(PBS)质子治疗中由于设置误差和射程不确定性造成的不确定性。此外，由于2 mm是最大的边际尺寸之一，我们还研究了2 mm均匀扩展的计划质量是否可以与其他计划方案相媲美。我们为OTV开发了两个方案：(1)2 mm的均匀扩展(OTV2 Mm)，用于设置不确定度；(2)基于水等厚的波束特定扩展(OTVWET)，在波束方向和2 mm的横向扩展。计划6例LAPC患者，处方剂量为33Gy5次/次。以设置不确定度为2 mm、范围不确定度为3.5%的大体肿瘤体积稳健性优化(RO)计划为基准。3种优化方案均达到了较好的目标复盖率，无显著差异。OTV2 mm平面显示较好的危险器官(OAR)保留，特别是对十二指肠近端。然而，OTV2 mm计划表现出对射程和设置不确定性的严重敏感性，19%的计划通过率达到了规定剂量覆盖95%的容量的目标。所提出的剂量扩散函数分析显示没有显著差异。OTVWET的使用在稳健优化中模拟了所有场景的联合体积，但显著地节省了优化时间。由于计划优化的效率，射束特定的边缘对在线自适应立体定向体质子治疗具有吸引力。
We investigate two margin-based schemes for optimization target volumes (OTV), both isotropic expansion (2 mm) and beam-specific OTV, to account for uncertainties due to the setup errors and range uncertainties in pancreatic stereotactic pencil beam scanning (PBS) proton therapy. Also, as 2-mm being one of the extreme sizes of margin, we also study whether the plan quality of 2-mm uniform expansion could be comparable to other plan schemes. We developed 2 schemes for OTV: (1) a uniform expansion of 2 mm (OTV2mm) for setup uncertainty and (2) a water equivalent thickness–based, beam-specific expansion (OTVWET) on beam direction and 2 mm expansion laterally. Six LAPC patients were planned with a prescribed dose of 33 Gy (RBE) in 5 fractions. Robustness optimization (RO) plans on gross tumor volumes, with setup uncertainties of 2 mm and range uncertainties of 3.5%, were implemented as a benchmark. All 3 optimization schemes achieved decent target coverage with no significant difference. The OTV2mm plans show superior organ at risk (OAR) sparing, especially for proximal duodenum. However, OTV2mm plans demonstrate severe susceptibility to range and setup uncertainties with a passing rate of 19% of the plans meeting the goal of 95% volume covered by the prescribed dose. The proposed dose spread function analysis shows no significant difference. The use of OTVWET mimics a union volume for all scenarios in robust optimization but saves optimization time noticeably. The beam-specific margin can be attractive to online adaptive stereotactic body proton therapy owing to the efficiency of the plan optimization.
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用于胰腺癌放射治疗的可生物降解水凝胶垫片保留十二指肠的剂量预测模型
DOI：
10.1016/j.ijrobp.2018.07.184
发表时间：
2018-11-01
期刊：
International journal of radiation oncology, biology, physics
影响因子：
--
作者：
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影响因子：
3.8
作者：
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通讯作者：
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影响因子：
3.8
作者：
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通讯作者：
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影响因子：
2.1
作者：
Kim SH;Ding K;Rao A;He J;Bhutani MS;Herman JM;Narang A;Shin EJ
通讯作者：
Shin EJ
影响因子：
2
作者：
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通讯作者：
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