Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing.
Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing.
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DOI：
10.3791/63085
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发表时间：
2021-10-20
期刊：
影响因子：
--
通讯作者：
Franz CK
中科院分区：
文献类型：
--
作者：
Wang H;D'Andrea D;Choi YS;Bouricha Y;Wickerson G;Ahn HY;Guo H;Huang Y;Sandhu MS;Jordan SW;Rogers JA;Franz CK
外周神经接口在实验神经科学和再生医学中有着广泛的应用。这些接口可以是传感器，执行器，或者两者兼而有之。传统的外周神经接口方法要么必须连接到外部系统，要么依赖电池供电，这限制了操作的时间框架。随着无线、无电池和完全植入式周围神经接口的最新发展，一类新的设备可以提供与有线或电池供电的设备相匹配或超过的功能。本文描述了在成年大鼠中(i)手术植入和（ii）无线供电和控制该系统的方法。我们选择坐骨神经和膈神经模型作为例子，以突出该入路的多功能性。本文展示了周围神经界面如何唤起复合肌肉动作电位（CMAPs），提供治疗性电刺激方案，并结合导管修复周围神经损伤。这种装置为单剂量或重复剂量的治疗刺激提供了扩展的治疗选择，并且可以适应各种神经位置。这是一份关于周围神经无线供电接口的手术植入和操作的协议。我们用放置在大鼠坐骨神经或膈神经上的神经刺激器的例子来证明这种方法的实用性。
Peripheral nerve interfaces are frequently used in experimental neuroscience and regenerative medicine for a wide variety of applications. Such interfaces can be sensors, actuators, or both. Traditional methods of peripheral nerve interfacing must either tether to an external system or rely on battery power that limits the time frame for operation. With recent developments of wireless, battery-free, and fully implantable peripheral nerve interfaces, a new class of devices can offer capabilities that match or exceed those of their wired or battery-powered precursors. This paper describes methods to (i) surgically implant and (ii) wirelessly power and control this system in adult rats. The sciatic and phrenic nerve models were selected as examples to highlight the versatility of this approach. The paper shows how the peripheral nerve interface can evoke compound muscle action potentials (CMAPs), deliver a therapeutic electrical stimulation protocol, and incorporate a conduit for the repair of peripheral nerve injury. Such devices offer expanded treatment options for single-dose or repeated dose therapeutic stimulation and can be adapted to a variety of nerve locations. This is a protocol for the surgical implantation and operation of a wirelessly powered interface for peripheral nerves. We demonstrate the utility of this approach with examples from nerve stimulators placed on either the rat sciatic or phrenic nerve.
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