Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade.
Nuclear expression of Survivin in paediatric ependymomas and choroid plexus tumours correlates with morphologic tumour grade.
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DOI：
10.1038/sj.bjc.6601334
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发表时间：
2003-11-03
影响因子：
8.8
通讯作者：
Boué DR
中科院分区：
文献类型：
--
作者：
Altura RA;Olshefski RS;Jiang Y;Boué DR
Survivin是一种在正常哺乳动物胚胎发育过程中广泛表达的基因。Survivin在细胞核和细胞质中的亚细胞定位表明了多种功能作用，包括抑制细胞死亡，特别是在各种恶性细胞类型中所证明的，以及调节有丝分裂纺锤体检查点。Survivin的表达与大量恶性肿瘤的不良临床结局相关。然而，在乳腺癌和胃癌的两项大型临床研究中，细胞核Survivin表达已被描述为有利预后的独立变量。Survivin在正常出生后分化组织中表达的报道仅限于具有高增殖能力的细胞类型，包括血管内皮、子宫内膜、结肠上皮和活化的淋巴细胞。在本报告之前，正常人脑内的表达尚未被表征。在这里，我们分析了生存素的表达在人脑切片从围产期和儿科尸检病例。我们报告了一个惊人的高水平的表达Survivin正常室管膜和脉络丛（CP）。对儿科室管膜瘤和CP肿瘤中相应的肿瘤组织的分析表明，Survivin的核形式表达与肿瘤的形态学分级相关，核表达的丧失与进行性细胞间变性相关。这种表达模式支持一种假设，即存活素在正常室管膜生长和/或神经干细胞分化中起功能作用，并且这种蛋白质的核形式的异常低水平表达可能是室管膜和CP肿瘤中更侵袭性疾病和/或更高形态学等级的标志物。
Survivin is a gene that is widely expressed throughout the development of the normal mammalian embryo. Subcellular localisation of Survivin to both the nucleus and cytoplasm has suggested multiple functional roles, including inhibition of cell death, especially as demonstrated within a variety of malignant cell types, as well as regulation of the mitotic spindle checkpoint. The expression of Survivin has been associated with an adverse clinical outcome in a large number of malignancies. However, nuclear Survivin expression has been described as an independent variable of favourable prognosis in two large clinical studies of breast and gastric carcinomas. Reports of Survivin expression in normal postnatal, differentiated tissues have been restricted to cell types with high proliferative capacities, including vascular endothelium, endometrium, colonic epithelium, and activated lymphocytes. Prior to this report, expression within the normal human brain had not been characterised. Here, we analyse the expression of Survivin in human brain sections obtained from perinatal and paediatric autopsy cases. We report a strikingly high level of expression of Survivin within normal ependyma and choroid plexus (CP). Analysis of corresponding neoplastic tissue in paediatric ependymomas and CP tumours shows that expression of the nuclear form of Survivin correlates with morphologic tumour grade, with a loss of nuclear expression associated with progressive cytologic anaplasia. This pattern of expression supports a hypothesis that Survivin plays a functional role in normal ependymal growth and/or neural stem cell differentiation, and that abnormally low levels of expression of the nuclear form of this protein may be a marker of more aggressive disease and/or higher morphologic grade in ependymal and CP tumours.
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影响因子：
45.3
作者：
Chakravarti, A;Noll, E;Loeffler, JS
通讯作者：
Loeffler, JS
胃癌中不同生存变异的表达：源于苏属-2b在肿瘤进展中的作用的第一线索。
影响因子：
8.8
作者：
Krieg, A;Mahotka, C;Krieg, T;Grabsch, H;Muller, W;Takeno, S;Suschek, C V;Heydthausen, M;Gabbert, H E;Gerharz, C D
通讯作者：
Gerharz, C D
影响因子：
9.7
作者：
Okada, E;Murai, Y;Takano, Y
通讯作者：
Takano, Y
影响因子：
3.7
作者：
Rodríguez, JA;Span, SW;Giaccone, G
通讯作者：
Giaccone, G
影响因子：
82.9
作者：
Ambrosini, G;Adida, C;Altieri, DC
通讯作者：
Altieri, DC