The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization.
The Role of Alternative Polyadenylation in the Regulation of Subcellular RNA Localization.
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DOI：
10.3389/fgene.2021.818668
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发表时间：
2021
影响因子：
3.7
通讯作者：
Taliaferro JM
中科院分区：
文献类型：
--
作者：
Arora A;Goering R;Lo HYG;Lo J;Moffatt C;Taliaferro JM
选择性多聚腺苷酸化（阿帕）是一种广泛存在的保守的mRNA 3′端调控机制。阿帕模式通常是组织特异性的，并在细胞过程中发挥重要作用，如细胞增殖，分化和应激反应。在3′ UTR中发现了许多阿帕位点，产生了具有不同3′ UTR含量的mRNA异构体。这些交替的3′ UTR异构体可以改变转录物的调节方式，影响其稳定性和翻译。由于转录本的亚细胞定位通常受3′ UTR序列的调节，这意味着阿帕也可以改变转录本的位置。然而，阿帕和RNA定位之间的这种联系只是最近才被探索。在这篇综述中，我们讨论了阿帕在mRNA定位在不同的亚细胞区室的作用。我们还讨论了当前的挑战和未来的进展，这将有助于我们了解阿帕如何影响RNA定位和驱动这些过程的分子机制。
Alternative polyadenylation (APA) is a widespread and conserved regulatory mechanism that generates diverse 3′ ends on mRNA. APA patterns are often tissue specific and play an important role in cellular processes such as cell proliferation, differentiation, and response to stress. Many APA sites are found in 3′ UTRs, generating mRNA isoforms with different 3′ UTR contents. These alternate 3′ UTR isoforms can change how the transcript is regulated, affecting its stability and translation. Since the subcellular localization of a transcript is often regulated by 3′ UTR sequences, this implies that APA can also change transcript location. However, this connection between APA and RNA localization has only recently been explored. In this review, we discuss the role of APA in mRNA localization across distinct subcellular compartments. We also discuss current challenges and future advancements that will aid our understanding of how APA affects RNA localization and molecular mechanisms that drive these processes.
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影响因子：
4.6
作者：
Fontes MM;Guvenek A;Kawaguchi R;Zheng D;Huang A;Ho VM;Chen PB;Liu X;O'Dell TJ;Coppola G;Tian B;Martin KC
通讯作者：
Martin KC
DOI：
10.1007/978-1-61779-005-8_19
发表时间：
2011
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
--
作者：
Jagannathan, Sujatha;Nwosu, Christine;Nicchitta, Christopher V
通讯作者：
Nicchitta, Christopher V
DOI：
10.1038/nrm3918
发表时间：
2015-02
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
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影响因子：
64.8
作者：
Hachet, O;Ephrussi, A
通讯作者：
Ephrussi, A
影响因子：
8.8
作者：
Cheng LC;Zheng D;Zhang Q;Guvenek A;Cheng H;Tian B
通讯作者：
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