Heightened perception of illusory motion is associated with symptom severity in schizophrenia patients
Heightened perception of illusory motion is associated with symptom severity in schizophrenia patients
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精神分裂症患者对错觉运动的感知增强与症状严重程度相关
DOI：
10.1016/j.pnpbp.2020.110055
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发表时间：
2020-08
期刊：
影响因子：
--
通讯作者：
Dengtang Liu
中科院分区：
文献类型：
--
作者：
Kristina Zeljic;Qiong Xiang;Zhiwei Wang;Yingying Pan;Yuequan Shi;Zuofu Zhou;Zheng Wang;Dengtang Liu
精神分裂症患者的异常知觉处理可能会导致幻觉等阳性症状的发展。实验结果表明，这种异常的结果，从受损的处理到复杂的皮层代表的本地信号。由于需要复杂的处理来从局部信号产生错觉运动的感知，因此精神分裂症患者的错觉运动感知会恶化。然而，研究结果是混合的，复杂的运动处理和症状之间的关系尚不清楚。具有多个流动成分（例如旋转/膨胀）的错觉被认为强烈地参与了可能在精神分裂症中异常的专门的复杂处理机制，但尚未被研究。我们使用了最近构建的范式的基础上Pinna-Brelstaff错觉操纵复杂的流动错觉的定量方式和探测协会与尺寸的症状。在102名患者和90名对照组中，在一系列参数范围内测量了PBF的感知速度和感知变异性。同时，记录眼球运动和凝视参数进行分析，以检查对错觉的影响。我们的研究结果表明，患者比对照组经历了更快的错觉旋转，而他们的眼睛注视更少。这种增强的错觉与积极的和一般的症状评分显着相关，但与消极的症状评分无关。我们的研究结果表明，不寻常的处理复杂的流运动的患者可能是具体相关的维度症状，这可能提供了一个有前途的策略，解析异质性精神分裂症综合征。这进一步突出了运动知觉异常在精神分裂症的病理生理学中的作用，从而鼓励未来对视觉补救疗法的研究。
Abnormal perceptual processing in schizophrenia may contribute to the development of positive symptoms such as hallucinations. Experimental findings suggest that such abnormalities result from impaired processing of local signals into complex cortical representations. Because complex processing is needed to generate the perception of illusory motion from local signals, deteriorated perception of illusory motion would be expected in schizophrenia. However, findings are mixed, and the relationship between complex motion processing and symptoms is unclear. Illusions with multiple flow components (e.g. rotation/expansion) are known to strongly engage specialized complex processing mechanisms that may be abnormal in schizophrenia, but have not yet been investigated. We used a recently constructed paradigm based on the Pinna-Brelstaff illusion to manipulate complex-flow illusory perception in a quantitative manner and probe associations with dimensional symptoms. In 102 patients and 90 controls, perceived speed and perceptual variability for the PBF were measured across a range of parameters. Meanwhile, eye movement was recorded and gaze parameters were analysed to examine effects on illusory perception. Our results showed that patients experienced faster illusory rotation than controls, while they made fewer eye fixations. This heightened illusory perception was significantly correlated with positive and general, but not negative, symptom scores. Our results indicate that unusual processing of complex-flow motion in patients may be specifically related to dimensional symptoms, which could provide a promising strategy for parsing heterogeneity in the schizophrenia syndrome. This further highlights the role of motion perception abnormalities in the pathophysiology of schizophrenia, thus encouraging future investigation into visual remediation therapeutics.
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影响因子：
10.6
作者：
Butler PD;Silverstein SM;Dakin SC
通讯作者：
Dakin SC
影响因子：
11.3
作者：
Grzeczkowski, Lukasz;Roinishvili, Maya;Shaqiri, Albulena
通讯作者：
Shaqiri, Albulena
DOI：
10.1007/s00406-012-0344-5
发表时间：
2013-04
影响因子：
4.7
作者：
L. L. O. Sanders-L.;W. de Millas;A. Heinz;N. Kathmann;P. Sterzer
通讯作者：
L. L. O. Sanders-L.;W. de Millas;A. Heinz;N. Kathmann;P. Sterzer
影响因子：
2.5
作者：
Nieuwenhuis, S;Broerse, A;de Jong, R
通讯作者：
de Jong, R
影响因子：
1.8
作者：
Cretenoud, Aline F.;Karimpur, Harun;Herzog, Michael H.
通讯作者：
Herzog, Michael H.