Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy.
Monte Carlo study of the potential reduction in out-of-field dose using a patient-specific aperture in pencil beam scanning proton therapy.
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DOI：
10.1088/0031-9155/57/10/2829
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发表时间：
2012-05-21
影响因子：
3.5
通讯作者：
Paganetti H
中科院分区：
文献类型：
--
作者：
Dowdell SJ;Clasie B;Depauw N;Metcalfe P;Rosenfeld AB;Kooy HM;Flanz JB;Paganetti H
本研究旨在确定在质子束扫描中使用患者特定孔径的潜在好处。为此，马萨诸塞州总医院 (MGH) 的笔形束扫描 (PBS) 质子治疗 (PT) 治疗头的精确蒙特卡罗模型是基于被动双散射 (DS) 系统的现有模型开发的。蒙特卡洛代码指定 MGH 的治疗头具有亚毫米精度。该代码是根据 MGH 进行的实验测量结果配置的。然后使用该模型来比较模拟双散射 (DS) 处理和 PBS 处理中的场外剂量。对于所探索的条件，PBS 中的半影比 DS 中更宽，导致吸收剂量和邻近主场边缘的等效剂量更高。对于距离场边缘大于 10 厘米的横向距离，PBS 中的剂量似乎低于 DS 中观察到的剂量。我们发现，在 PBS 治疗期间在喷嘴出口处放置患者专用孔径可以潜在地将主辐射场横向的剂量减少一个数量级以上。总之，使用患者专用孔径有可能进一步提高 PBS 保护正常组织的能力。
This study aimed at identifying the potential benefits of using a patient specific aperture in proton beam scanning. For this purpose an accurate Monte Carlo model of the pencil beam scanning (PBS) proton therapy (PT) treatment head at Massachusetts General Hospital (MGH) was developed based on an existing model of the passive double-scattering (DS) system. The Monte Carlo code specifies the treatment head at MGH with sub-millimeter accuracy. The code was configured based on the results of experimental measurements performed at MGH. This model was then used to compare out-of-field doses in simulated double-scattering (DS) treatments and PBS treatments For the conditions explored, the penumbra in PBS is wider than in DS, leading to higher absorbed doses and equivalent doses adjacent to the primary field edge. For lateral distances greater than 10cm from the field edge, the doses in PBS appear to be lower than those observed for DS. We found that placing a patient-specific aperture at nozzle exit during PBS treatments can potentially reduce doses lateral to the primary radiation field by over an order of magnitude. In conclusion, using a patient-specific aperture has the potential to further improve the normal tissue sparing capabilities of PBS.
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影响因子：
3.8
作者：
Clasie, Ben;Wroe, Andrew;Rosenfeld, Anatoly
通讯作者：
Rosenfeld, Anatoly
DOI：
10.1016/s0360-3016(01)02826-7
发表时间：
2002-05-01
影响因子：
7
作者：
Schneider, U;Agosteo, S;Besserer, J
通讯作者：
Besserer, J
影响因子：
3.8
作者：
Paganetti, H;Jiang, H;Kooy, HM
通讯作者：
Kooy, HM
影响因子：
3.8
作者：
Dowdell, Stephen;Clasie, Ben;Rosenfeld, Anatoly
通讯作者：
Rosenfeld, Anatoly
影响因子：
3.5
作者：
Paganetti, Harald
通讯作者：
Paganetti, Harald