Spinal dura mater: biophysical characteristics relevant to medical device development.
Spinal dura mater: biophysical characteristics relevant to medical device development.
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DOI：
10.1080/03091902.2018.1435745
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发表时间：
2018-03
影响因子：
--
通讯作者：
Wilson S
中科院分区：
文献类型：
--
作者：
Nagel SJ;Reddy CG;Frizon LA;Chardon MK;Holland M;Machado AG;Gillies GT;Howard MA 3rd;Wilson S
了解脊髓硬脊膜的相关生物物理特性对于设计将直接与该膜相互作用或影响硬膜内空间内容物的医疗器械至关重要。我们查阅了文献，并综述了用于穿透、整合、粘附或置于脊髓硬脊膜内外的新型器械在设计、构造、测试和成像方面的相关特性。脊髓硬脊膜是一层由胶原纤维和弹性纤维组成的薄管状膜，其周长沿长度方向有所变化。其力学特性已得到充分描述，纵向抗拉强度超过横向强度。关于脊髓硬脊膜的生物电、生物磁、光学和热学特性的数据有限，有时被认为与水的相关特性相似。虽然有多种方法可用于观察脊髓硬脊膜，但磁共振仍然是分割其结构的最佳方法。脊髓硬脊膜对异物植入或其他操作的反应可能会损害其生物力学和免疫保护作用。因此，硬脊膜密封剂和替代物具有特殊的临床、研究和商业价值。总之，目前临床上用于脊髓刺激、鞘内给药或硬膜内植入的器械在很大程度上遵循传统设计及其相关局限性。然而，如果未来的器械在设计时能更充分地考虑硬脊膜的特性，就有可能提高性能。
Understanding the relevant biophysical properties of the spinal dura mater is essential to the design of medical devices that will directly interact with this membrane or influence the contents of the intradural space. We searched the literature and reviewed the pertinent characteristics for the design, construction, testing, and imaging of novel devices intended to perforate, integrate, adhere or reside within or outside of the spinal dura mater. The spinal dura mater is a thin tubular membrane composed of collagen and elastin fibres that varies in circumference along its length. Its mechanical properties have been well-described, with the longitudinal tensile strength exceeding the transverse strength. Data on the bioelectric, biomagnetic, optical and thermal characteristics of the spinal dura are limited and sometimes taken to be similar to those of water. While various modalities are available to visualise the spinal dura, magnetic resonance remains the best modality to segment its structure. The reaction of the spinal dura to imposition of a foreign body or other manipulations of it may compromise its biomechanical and immune-protective benefits. Therefore, dural sealants and replacements are of particular clinical, research and commercial interest. In conclusion, existing devices that are in clinical use for spinal cord stimulation, intrathecal access or intradural implantation largely adhere to traditional designs and their attendant limitations. However, if future devices are built with an understanding of the dura’s properties incorporated more fully into the designs, there is potential for improved performance.
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影响因子：
2.4
作者：
GROEN, GJ;BALJET, B;DRUKKER, J
通讯作者：
DRUKKER, J
影响因子：
1.9
作者：
Kaufman, Bruce A.;Matthews, Anne E.;Lew, Sean M.
通讯作者：
Lew, Sean M.
影响因子：
2.4
作者：
Hakky, Michael M.;Justaniah, Almamoon I.;Erbay, Sami H.
通讯作者：
Erbay, Sami H.
硬脑膜密封中的纤维蛋白密封剂：系统文献综述。
影响因子：
3.7
作者：
Esposito F;Angileri FF;Kruse P;Cavallo LM;Solari D;Esposito V;Tomasello F;Cappabianca P
通讯作者：
Cappabianca P
影响因子：
0.6
作者：
Genina, ÉA;Bashkatov, AN;Tuchin, VV
通讯作者：
Tuchin, VV