The corticothalamocortical circuit drives higher-order cortex in the mouse.
The corticothalamocortical circuit drives higher-order cortex in the mouse.
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DOI：
10.1038/nn.2449
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发表时间：
2010-01
影响因子：
25
通讯作者：
Sherman SM
中科院分区：
文献类型：
--
作者：
Theyel BB;Llano DA;Sherman SM
神经科学中一个尚未解决的问题涉及到从5 B层发出的皮质丘脑皮质回路在通过皮质层次结构的信息传递中发挥作用的程度。在这里，使用一种新的形式的光学成像的脑切片制备，我们证明了皮质丘脑皮质通路驱动器强大的活动，在高阶体感皮层。当直接的皮质通路被中断时，次级躯体感觉皮层表现出对初级躯体感觉皮层（S1 BF）的桶场刺激的强烈反应，该刺激在随后切割躯体感觉丘脑后被消除，这表明了一种非常有效的皮质-丘脑-皮质回路。此外，在化学抑制丘脑后，次级躯体感觉皮层的激活被消除，随后在洗脱后恢复。最后，刺激S1 BF中的5 B层而不是6层驱动了皮质丘脑皮质激活。这些研究结果表明，皮质丘脑皮质电路是一个生理上可行的候选人的信息传递到高阶皮层区域。
An unresolved question in neuroscience relates to the extent to which corticothalamocortical circuits emanating from layer 5B play a role in information transfer through the cortical hierarchy. Here, using a novel form of optical imaging in a brain slice preparation, we demonstrate that the corticothalamocortical pathway drives robust activity in higher-order somatosensory cortex. When the direct corticocortical pathway was interrupted, secondary somatosensory cortex showed robust activity in response to stimulation of the barrel field in primary somatosensory cortex (S1BF), which was eliminated after subsequently cutting the somatosensory thalamus, suggesting a highly efficacious corticothalamocortical circuit. Further, after chemically inhibiting the thalamus, activation in secondary somatosensory cortex was eliminated, with a subsequent return after washout. Finally, stimulation of layer 5B in S1BF, and not layer 6, drove corticothalamocortical activation. These findings suggest that the corticothalamocortical circuit is a physiologically viable candidate for information transfer to higher-order cortical areas.
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影响因子：
2.5
作者：
Lee, Charles C.;Sherman, S. Murray
通讯作者：
Sherman, S. Murray
影响因子：
2.5
作者：
Llano, D. A.;Theyel, B. B.;Issa, N. P.
通讯作者：
Issa, N. P.
影响因子：
2.5
作者：
MATHERS, LH
通讯作者：
MATHERS, LH
影响因子：
2.8
作者：
BAJO, VM;ROUILLER, EM;DERIBAUPIERRE, F
通讯作者：
DERIBAUPIERRE, F
影响因子：
2.5
作者：
DIAMOND, ME;ARMSTRONGJAMES, M;EBNER, FF
通讯作者：
EBNER, FF