Decreasing hospital burden of COVID-19 during the first wave in Regione Lombardia: an emergency measures context.
Decreasing hospital burden of COVID-19 during the first wave in Regione Lombardia: an emergency measures context.
复制标题
在伦巴第局的第一波中减轻了Covid-19的医院负担：紧急措施。
DOI：
10.1186/s12889-021-11669-w
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发表时间：
2021-09-03
影响因子：
4.5
通讯作者：
Covid-19 Lombardy Working Group
中科院分区：
文献类型：
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作者：
Grosso FM;Presanis AM;Kunzmann K;Jackson C;Corbella A;Grasselli G;Andreassi A;Bodina A;Gramegna M;Castaldi S;Cereda D;Angelis D;Covid-19 Lombardy Working Group
本研究的目的是量化第一波COVID-19期间的医院负担及其在日历时间内的变化;根据为管理二级医疗压力而采取的紧急措施来解释结果。这是一项队列研究，对2020年2月至6月收治的COVID-19住院确诊病例进行了随访，直至2020年7月17日，使用混合多状态模型进行分析。所有在Regione隆巴迪亚确诊COVID-19疾病的住院患者均参与，于2020年2月至6月期间入院，无入院医院缺失和入院日期缺失。该队列由第一波住院的40，550名患者组成。这些患者的中位年龄为69岁（四分位距56-80），男性（60%）比女性（40%）更有可能。所有住院途径的平均住院死亡风险为27.5%（95% CI 27.1-28.0%）;从2月的34.6%（32.5-36.6%）稳步下降至6月的7.6%（6.3-10.6%）。在存活患者中，中位住院时间为11.8（11.6-12.3）天，而非存活者为8.1（7.8-8.5）天。平均最终结果，住院时间中位数从2月的21.4（20.5-22.8）天下降到6月的5.2（4.7-5.8）天。就预后不良风险和住院时间而言，医院负担已被证明在第一波疫情的几个月内有所下降，这可能反映了对COVID-19病例的治疗和管理有所改善，以及随着第一波疫情的减弱，负担有所减轻。量化的负担允许规划当前和未来SARS-CoV-2 i浪潮所需的医院床位。在线版本包含补充材料，可通过10.1186/s12889-021-11669-w获得。
The aim of this study is to quantify the hospital burden of COVID-19 during the first wave and how it changed over calendar time; to interpret the results in light of the emergency measures introduced to manage the strain on secondary healthcare. This is a cohort study of hospitalised confirmed cases of COVID-19 admitted from February–June 2020 and followed up till 17th July 2020, analysed using a mixture multi-state model. All hospital patients with confirmed COVID-19 disease in Regione Lombardia were involved, admitted from February–June 2020, with non-missing hospital of admission and non-missing admission date. The cohort consists of 40,550 patients hospitalised during the first wave. These patients had a median age of 69 (interquartile range 56–80) and were more likely to be men (60%) than women (40%). The hospital-fatality risk, averaged over all pathways through hospital, was 27.5% (95% CI 27.1–28.0%); and steadily decreased from 34.6% (32.5–36.6%) in February to 7.6% (6.3–10.6%) in June. Among surviving patients, median length of stay in hospital was 11.8 (11.6–12.3) days, compared to 8.1 (7.8–8.5) days in non-survivors. Averaged over final outcomes, median length of stay in hospital decreased from 21.4 (20.5–22.8) days in February to 5.2 (4.7–5.8) days in June. The hospital burden, in terms of both risks of poor outcomes and lengths of stay in hospital, has been demonstrated to have decreased over the months of the first wave, perhaps reflecting improved treatment and management of COVID-19 cases, as well as reduced burden as the first wave waned. The quantified burden allows for planning of hospital beds needed for current and future waves of SARS-CoV-2 i. The online version contains supplementary material available at 10.1186/s12889-021-11669-w.
影响因子：
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作者：
O'Brien, Sean M.;DeLong, Elizabeth R.;Peterson, Eric D.
通讯作者：
Peterson, Eric D.
影响因子：
3.9
作者：
Boëlle PY;Delory T;Maynadier X;Janssen C;Piarroux R;Pichenot M;Lemaire X;Baclet N;Weyrich P;Melliez H;Meybeck A;Lanoix JP;Robineau O
通讯作者：
Robineau O