Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences.
Origin of imported SARS-CoV-2 strains in The Gambia identified from whole genome sequences.
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DOI：
10.1371/journal.pone.0241942
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Sesay AK
中科院分区：
文献类型：
--
作者：
Kanteh A;Manneh J;Jabang S;Kujabi MA;Sanyang B;Oboh MA;Bojang A;Jallow HS;Nwakanma D;Secka O;Roca A;Amambua-Ngwa A;Antonio M;Baldeh I;Forrest K;Samateh AL;D'Alessandro U;Sesay AK
2019 年 12 月在中国武汉首次发现的 SARS-CoV-2 疾病已成为全球大流行病，给全球医疗保健系统和经济造成前所未有的负担。虽然指示病例的旅行史可能表明感染源，但对这些病例和接触者中分离出的菌株进行系统发育分析将增加对当地传播与全球其他人群之间的了解和联系。该分析的目的是提供冈比亚前六例 SARS-CoV-2 病例的基因组数据并确定感染源。这最终为后续本地传输提供基线数据，并为本地和全球数据贡献基因组多样性信息。我们的分析表明，在冈比亚发现的 SARS-CoV-2 病毒源自欧洲和亚洲，并且测序数据与患者的旅行史相匹配。此外，我们还发现乘坐同一航班的两名 COVID-19 阳性病例携带不同的 SARS-CoV-2 毒株。尽管全基因组测序 (WGS) 数据在撒哈拉以南非洲地区仍然有限，但这种方法已被证明是 SARS-CoV-2 检测的高度敏感、特异和确证的工具。
The SARS-CoV-2 disease, first detected in Wuhan, China, in December 2019 has become a global pandemic and is causing an unprecedented burden on health care systems and the economy globally. While the travel history of index cases may suggest the origin of infection, phylogenetic analysis of isolated strains from these cases and contacts will increase the understanding and link between local transmission and other global populations. The objective of this analysis was to provide genomic data on the first six cases of SARS-CoV-2 in The Gambia and to determine the source of infection. This ultimately provide baseline data for subsequent local transmission and contribute genomic diversity information towards local and global data. Our analysis has shown that the SARS-CoV-2 virus identified in The Gambia are of European and Asian origin and sequenced data matched patients’ travel history. In addition, we were able to show that two COVID-19 positive cases travelling in the same flight had different strains of SARS-CoV-2. Although whole genome sequencing (WGS) data is still limited in sub-Saharan Africa, this approach has proven to be a highly sensitive, specific and confirmatory tool for SARS-CoV-2 detection.
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