Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond.
Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond.
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DOI：
10.3390/cancers12123765
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发表时间：
2020-12-14
期刊：
影响因子：
5.2
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Zhang X;Powell K;Li L
乳腺癌干细胞被认为是乳腺癌肿瘤发生、转移、耐药性和肿瘤复发的原因。因此，识别这一细胞亚群并了解其分子机制对于制定乳腺癌治疗策略至关重要。在此，我们从可用的生物标志物、鉴定和分离方法、分子机制以及研究其细胞起源和谱系发育的方法等方面回顾了乳腺癌干细胞研究的最新进展。尽管诊断和治疗方面最近取得了进展，但乳腺癌（BC）仍然是女性癌症相关死亡的主要原因。乳腺癌干细胞（BCSC）是异质性乳腺癌细胞的一个小而重要的亚群，表现出强大的自我更新和增殖特性。越来越多的证据证明BCSC是BC肿瘤发生、进展、转移、耐药和复发的驱动力。作为一种异质性疾病，BC 包含全谱不同的 BC 亚型，不同的 BC 亚型进一步表现出不同的 BCSC 亚型和比例，对应于不同的治疗反应和疾病特异性结果。本综述总结了 BCSC 生物标志物的最新知识及其临床相关性、BCSC 的识别和分离方法以及 BCSC 的调节机制。我们还讨论了 BCSC 的细胞起源以及单细胞谱系追踪和转录组学的最新进展及其在识别 BCSC 起源和谱系发育方面的潜力。
Breast cancer stem cells are blamed to be responsible for breast cancer tumorigenesis, metastasis, drug resistance and tumor recurrence. Therefore, it is critical to identify this subset of cells and understand their molecular mechanisms for the development of breast cancer treatment strategies. Here, we review the recent advances in breast cancer stem cell studies in terms of available biomarkers, identification and isolation methods, molecular mechanisms, and methods for studying their cellular origin and lineage development. Despite recent advances in diagnosis and treatment, breast cancer (BC) is still a major cause of cancer-related mortality in women. Breast cancer stem cells (BCSCs) are a small but significant subpopulation of heterogeneous breast cancer cells demonstrating strong self-renewal and proliferation properties. Accumulating evidence has proved that BCSCs are the driving force behind BC tumor initiation, progression, metastasis, drug resistance, and recurrence. As a heterogeneous disease, BC contains a full spectrum of different BC subtypes, and different subtypes of BC further exhibit distinct subtypes and proportions of BCSCs, which correspond to different treatment responses and disease-specific outcomes. This review summarized the current knowledge of BCSC biomarkers and their clinical relevance, the methods for the identification and isolation of BCSCs, and the mechanisms regulating BCSCs. We also discussed the cellular origin of BCSCs and the current advances in single-cell lineage tracing and transcriptomics and their potential in identifying the origin and lineage development of BCSCs.
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影响因子：
2.9
作者：
Albini A;Bruno A;Gallo C;Pajardi G;Noonan DM;Dallaglio K
通讯作者：
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影响因子：
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