In vivo sodium MR imaging of the abdomen at 3T.
In vivo sodium MR imaging of the abdomen at 3T.
复制标题
DOI：
10.1007/s00261-015-0428-6
复制
发表时间：
2015-10
影响因子：
--
通讯作者：
Bansal N
中科院分区：
文献类型：
--
作者：
James JR;Panda A;Lin C;Dydak U;Dale BM;Bansal N
跨膜钠(23Na)梯度是细胞存活和存活的关键，也是抗癌药物开发和治疗的靶点，因为它是信号转导。在临床环境中集成腹部23Na磁共振成像的能力将有助于非侵入性检测和诊断各种器官系统的许多疾病。我们在这项工作中的目标是使用3特斯拉磁共振扫描仪和新型8通道相控阵双调23Na和1H发射(Tx)/接收(Rx)线圈来提高腹部23Na MRI的质量，该线圈专门设计用于成像具有相对高信噪比的腹部大区域。改进的GRE成像序列被优化用于23Na磁共振成像，以获得在模体和志愿者中获得SNR、空间分辨率和扫描时间的最佳组合。根据校正后的~(23)Na磁共振绝对定量计算全腹部组织钠浓度(TSC)。此外，还对正常志愿者~(23)Na核磁共振测量的体内重复性和可靠性进行了评估。利用新型8通道双调谐23Na和1H发射/接收线圈，在15min内获得了高空间分辨率(0.3 cm)和信噪比(~20)的全腹部23Na轴位图像。对钠图像的定量分析估计，健康志愿者肝脏的平均TSC为20.13 mm。我们的结果表明，在临床实践中，使用多通道表面线圈在临床可接受的扫描时间内获得高分辨率的23Na图像是可行的，并且具有良好的信噪比。
Transmembrane sodium (23Na) gradient is critical for cell survival and viability and a target for the development of anti-cancer drugs and treatment as it serves as a signal transducer. The ability to integrate abdominal 23Na MRI in clinical settings would be useful to non-invasively detect and diagnose a number of diseases in various organ systems. Our goal in this work was to enhance the quality of 23Na MRI of the abdomen using a 3-Tesla MR scanner and a novel 8-channel phased-array dual-tuned 23Na and 1H transmit (Tx)/ receive (Rx) coil specially designed to image a large abdomen region with relatively high SNR. A modified GRE imaging sequence was optimized for 23Na MRI to obtain the best possible combination of SNR, spatial resolution, and scan time in phantoms as well as volunteers. Tissue sodium concentration (TSC) of the whole abdomen was calculated from the inhomogeneity-corrected 23Na MRI for absolute quantification. In addition, in vivo reproducibility and reliability of TSC measurements from 23Na MRI was evaluated in normal volunteers. 23Na axial images of the entire abdomen with a high spatial resolution (0.3 cm) and SNR (~20) in 15 min using the novel 8-channel dual-tuned 23Na and 1H transmit/receive coil were obtained. Quantitative analysis of the sodium images estimated a mean TSC of the liver to be 20.13 mM in healthy volunteers. Our results have shown that it is feasible to obtain high-resolution 23Na images using a multi-channel surface coil with good SNR in clinically acceptable scan times in clinical practice for various body applications.
登录
查看更多内容
影响因子：
3.3
作者：
Babsky, Andriy M.;Topper, Stephen;Bansal, Navin
通讯作者：
Bansal, Navin
DOI：
10.1055/s-0031-1299277
发表时间：
2012-04-01
影响因子：
1.8
作者：
Henzler, T.;Konstandin, S.;Fink, C.
通讯作者：
Fink, C.
影响因子：
3.8
作者：
Ouwerkerk, Ronald;Jacobs, Michael A.;Bottomley, Paul A.
通讯作者：
Bottomley, Paul A.
影响因子：
4.8
作者：
Rosen, Yael;Lenkinski, Robert E.
通讯作者：
Lenkinski, Robert E.
影响因子：
19.7
作者：
Rofsky, NM;Lee, VS;Weinreb, JC
通讯作者：
Weinreb, JC