Multilayer-omics analyses of human cancers: exploration of biomarkers and drug targets based on the activities of the International Human Epigenome Consortium.
Multilayer-omics analyses of human cancers: exploration of biomarkers and drug targets based on the activities of the International Human Epigenome Consortium.
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DOI：
10.3389/fgene.2014.00024
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发表时间：
2014
影响因子：
3.7
通讯作者：
Arai E
中科院分区：
文献类型：
--
作者：
Kanai Y;Arai E
主要由DNA甲基化改变和组蛋白修饰改变组成的表观遗传改变经常在与慢性炎症和/或病毒或其他病原微生物的持续感染或与吸烟相关的癌症中观察到。越来越多的证据表明，DNA甲基化的改变甚至涉及早期和癌前阶段。另一方面，在癌症患者中，异常DNA甲基化通常与肿瘤侵袭性和患者预后不良相关。最近，表观基因组改变已经吸引了研究人员的大量关注，他们不仅关注癌症，还关注神经元，免疫和代谢疾病。为了准确鉴定可能潜在地适用于疾病预防、诊断和治疗的疾病特异性表观基因组谱，与正常组织的标准表观基因组谱进行严格比较是必不可少的。然而，表观基因组机制显示组织和细胞谱系之间的异质性。因此，获得正常组织的标准表观基因组谱的全面图片并不容易。2010年，国际人类表观基因组联盟（IHEC）成立，以协调关键细胞状态的人类表观基因组参考图谱的制作。为了获得对人类表观基因组的实质性覆盖，IHEC设定了一个雄心勃勃的目标，即在未来7-10年内破译至少1000个表观基因组。我们认为，使用显示多层组学异常的基因（包括基因组、表观基因组、转录组、蛋白质组和代谢组异常）进行通路分析可能有助于阐明发病机制的分子背景和探索每种疾病的可能治疗靶点。
Epigenetic alterations consisting mainly of DNA methylation alterations and histone modification alterations are frequently observed in cancers associated with chronic inflammation and/or persistent infection with viruses or other pathogenic microorganisms, or with cigarette smoking. Accumulating evidence suggests that alterations of DNA methylation are involved even in the early and precancerous stages. On the other hand, in patients with cancers, aberrant DNA methylation is frequently associated with tumor aggressiveness and poor patient outcome. Recently, epigenome alterations have been attracting a great deal of attention from researchers who are focusing on not only cancers but also neuronal, immune and metabolic disorders. In order to accurately identify disease-specific epigenome profiles that could be potentially applicable for disease prevention, diagnosis and therapy, strict comparison with standard epigenome profiles of normal tissues is indispensable. However, epigenome mechanisms show heterogeneity among tissues and cell lineages. Therefore, it is not easy to obtain a comprehensive picture of standard epigenome profiles of normal tissues. In 2010, the International Human Epigenome Consortium (IHEC) was established to coordinate the production of reference maps of human epigenomes for key cellular states. In order to gain substantial coverage of the human epigenome, the IHEC has set an ambitious goal to decipher at least 1000 epigenomes within the next 7–10 years. We consider that pathway analysis using genes showing multilayer-omics abnormalities, including genome, epigenome, transcriptome, proteome and metabolome abnormalities, may be useful for elucidating the molecular background of pathogenesis and for exploring possible therapeutic targets for each disease.
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影响因子：
8
作者：
Saito, Y.;Suzuki, H.;Hibi, T.
通讯作者：
Hibi, T.
影响因子：
6.4
作者：
Sato, Takashi;Arai, Eri;Kohno, Takashi;Takahashi, Yoriko;Miyata, Sayaka;Tsuta, Koji;Watanabe, Shun-ichi;Soejima, Kenzo;Betsuyaku, Tomoko;Kanai, Yae
通讯作者：
Kanai, Yae
DOI：
10.1073/pnas.0808830105
发表时间：
2008-10-21
影响因子：
11.1
作者：
Kim, Daniel H.;Saetrom, Pal;Rossi, John J.
通讯作者：
Rossi, John J.
影响因子：
--
作者：
Gotoh M;Arai E;Wakai-Ushijima S;Hiraoka N;Kosuge T;Hosoda F;Shibata T;Kondo T;Yokoi S;Imoto I;Inazawa J;Kanai Y
通讯作者：
Kanai Y
影响因子：
3.8
作者：
Arai, Eri;Kanai, Yae
通讯作者：
Kanai, Yae