Neuromodulatory Systems and Their Interactions: A Review of Models, Theories, and Experiments.
Neuromodulatory Systems and Their Interactions: A Review of Models, Theories, and Experiments.
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DOI：
10.3389/fncir.2017.00108
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发表时间：
2017
影响因子：
3.5
通讯作者：
Krichmar JL
中科院分区：
文献类型：
--
作者：
Avery MC;Krichmar JL
神经调节系统，包括去甲肾上腺素能、多巴胺能、胆碱能系统，跟踪环境信号，如风险、回报、新奇、努力和社会合作。这些系统为高等生物的认知功能提供了基础;注意力、情感、目标导向行为和决策都来自神经调节系统与大脑区域（如杏仁核、额叶皮质、海马和感觉皮质）之间的相互作用。鉴于它们对行为和认知的强烈影响，这些系统在疾病状态中也起着关键作用，并且是许多当前治疗策略的主要目标。然而，这些系统直接或间接地相互作用的事实使得很难理解一个或多个系统的故障如何导致特定的症状或病理。在这篇综述中，我们探讨了实验证据，以及专注于神经调制的计算和理论模型。更好地了解神经调节系统可能会导致一些脑疾病的新的治疗策略的发展。
Neuromodulatory systems, including the noradrenergic, serotonergic, dopaminergic, and cholinergic systems, track environmental signals, such as risks, rewards, novelty, effort, and social cooperation. These systems provide a foundation for cognitive function in higher organisms; attention, emotion, goal-directed behavior, and decision-making derive from the interaction between the neuromodulatory systems and brain areas, such as the amygdala, frontal cortex, hippocampus, and sensory cortices. Given their strong influence on behavior and cognition, these systems also play a key role in disease states and are the primary target of many current treatment strategies. The fact that these systems interact with each other either directly or indirectly, however, makes it difficult to understand how a failure in one or more systems can lead to a particular symptom or pathology. In this review, we explore experimental evidence, as well as focus on computational and theoretical models of neuromodulation. Better understanding of neuromodulatory systems may lead to the development of novel treatment strategies for a number of brain disorders.
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影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
3.5
作者：
Caetano MS;Jin LE;Harenberg L;Stachenfeld KL;Arnsten AF;Laubach M
通讯作者：
Laubach M
影响因子：
3.2
作者：
Balasubramani PP;Chakravarthy VS;Ravindran B;Moustafa AA
通讯作者：
Moustafa AA
影响因子：
3.2
作者：
Avery MC;Nitz DA;Chiba AA;Krichmar JL
通讯作者：
Krichmar JL
影响因子：
4.1
作者：
Bedard, Catherine;Wallman, Marie-Josee;Parent, Martin
通讯作者：
Parent, Martin