Simulation of cholinergic and noradrenergic modulation of behavior in uncertain environments.
Simulation of cholinergic and noradrenergic modulation of behavior in uncertain environments.
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DOI：
10.3389/fncom.2012.00005
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发表时间：
2012
影响因子：
3.2
通讯作者：
Krichmar JL
中科院分区：
文献类型：
--
作者：
Avery MC;Nitz DA;Chiba AA;Krichmar JL
注意力是一个复杂的神经生物学过程，它涉及快速灵活地平衡感官输入和目标导向的预测，以应对环境变化。胆碱能和去甲肾上腺素能系统，这已被提出来响应预期和意想不到的环境不确定性，分别发挥了重要的作用，在注意力的差异调节活动在众多的皮层目标。在这里，我们开发了一个模型的注意力任务，涉及预期和意外的不确定性。胆碱能和去甲肾上腺素能系统追踪这种不确定性，反过来，以五种不同的实验验证的方式影响皮层处理：（1）丘脑皮质输入的烟碱增强，（2）皮质皮质反馈的毒蕈碱调节，（3）网络重置的去甲肾上腺素能介导，（4）基底前脑（BF）的蓝斑（LC）激活，（5）感觉输入和额叶皮质预测之间的胆碱能和去甲肾上腺素能平衡。我们的研究结果揭示了去甲肾上腺素能和胆碱能系统如何相互作用和一组分布式的神经区域，以及这如何导致行为适应面对的不确定性。
Attention is a complex neurobiological process that involves rapidly and flexibly balancing sensory input and goal-directed predictions in response to environmental changes. The cholinergic and noradrenergic systems, which have been proposed to respond to expected and unexpected environmental uncertainty, respectively, play an important role in attention by differentially modulating activity in a multitude of cortical targets. Here we develop a model of an attention task that involves expected and unexpected uncertainty. The cholinergic and noradrenergic systems track this uncertainty and, in turn, influence cortical processing in five different, experimentally verified ways: (1) nicotinic enhancement of thalamocortical input, (2) muscarinic regulation of corticocortical feedback, (3) noradrenergic mediation of a network reset, (4) locus coeruleus (LC) activation of the basal forebrain (BF), and (5) cholinergic and noradrenergic balance between sensory input and frontal cortex predictions. Our results shed light on how the noradrenergic and cholinergic systems interact with each other and a distributed set of neural areas, and how this could lead to behavioral adaptation in the face of uncertainty.
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DOI：
10.1196/annals.1417.021
发表时间：
2008-01-01
期刊：
MOLECULAR AND BIOPHYSICAL MECHANISMS OF AROUSAL, ALERTNESS, AND ATTENTION
影响因子：
--
作者：
Parikh, Vinay;Sarter, Martin
通讯作者：
Sarter, Martin
影响因子：
25
作者：
Vogels, Tim P.;Abbott, L. F.
通讯作者：
Abbott, L. F.
影响因子：
16.2
作者：
Yu, AJ;Dayan, P
通讯作者：
Dayan, P
影响因子：
2.5
作者：
Aston-Jones, G;Cohen, JD
通讯作者：
Cohen, JD
影响因子：
64.8
作者：
Herrero, J. L.;Roberts, M. J.;Delicato, L. S.;Gieselmann, M. A.;Dayan, P.;Thiele, A.
通讯作者：
Thiele, A.