An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution.
An agent-based model clarifies the importance of functional and developmental integration in shaping brain evolution.
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基于代理的模型阐明了功能和发育整合在塑造大脑进化中的重要性。
DOI：
10.1186/s12915-021-01024-1
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发表时间：
2021-05-10
期刊：
影响因子：
5.4
通讯作者：
Montgomery SH
中科院分区：
文献类型：
--
作者：
Avin S;Currie A;Montgomery SH
脊椎动物大脑结构的特征不仅在于组件之间的比例相对一致，而且还包括许多与这些一般趋势不同的例子。替代假说通过强调“外部”过程（如协调或发散选择）或“内部”过程（如大脑区域之间的发育耦合）来解释这些模式。虽然这些假设并不相互排斥，但对于它们在时间上的相对重要性或这种重要性如何在进化背景下变化，人们几乎没有达成一致。我们引入了一个基于代理的模型来模拟大脑进化的“裸骨”系统和研究变量之间的依赖关系塑造大脑进化。我们表明，“协调一致”的大脑进化模式本身并不提供证据的发展耦合，尽管这些条款往往被视为同义词在文献中。相反，协同进化可以反映功能或发育整合。我们的模型进一步使我们能够澄清条件下，这种发展的耦合，或解耦合，是潜在的适应性，揭示支持维护这两种机制在神经进化。重要的是，我们说明了偏离协同进化的概率如何取决于神经组织的成本/效益比，当整体大脑大小本身受到限制时，神经组织的成本/效益比会增加。我们的结论是，发育耦合和非耦合的大脑架构可以提供自适应机制，这取决于选择分布在大脑结构，生活史和神经组织的成本。然而，当限制也作用于大脑的整体大小时，大脑结构之间选择的异质性将有利于区域特异性或马赛克进化。无论如何，发育耦合和非耦合大脑结构的各自优势意味着两者都可以在波动的环境中持续存在。这意味着，发展耦合不太可能是一个持久的约束，但可能演变为一个适应性的选择，以保持功能整合的结果。
Vertebrate brain structure is characterised not only by relative consistency in scaling between components, but also by many examples of divergence from these general trends.. Alternative hypotheses explain these patterns by emphasising either ‘external’ processes, such as coordinated or divergent selection, or ‘internal’ processes, like developmental coupling among brain regions. Although these hypotheses are not mutually exclusive, there is little agreement over their relative importance across time or how that importance may vary across evolutionary contexts. We introduce an agent-based model to simulate brain evolution in a ‘bare-bones’ system and examine dependencies between variables shaping brain evolution. We show that ‘concerted’ patterns of brain evolution do not, in themselves, provide evidence for developmental coupling, despite these terms often being treated as synonymous in the literature. Instead, concerted evolution can reflect either functional or developmental integration. Our model further allows us to clarify conditions under which such developmental coupling, or uncoupling, is potentially adaptive, revealing support for the maintenance of both mechanisms in neural evolution. Critically, we illustrate how the probability of deviation from concerted evolution depends on the cost/benefit ratio of neural tissue, which increases when overall brain size is itself under constraint. We conclude that both developmentally coupled and uncoupled brain architectures can provide adaptive mechanisms, depending on the distribution of selection across brain structures, life history and costs of neural tissue. However, when constraints also act on overall brain size, heterogeneity in selection across brain structures will favour region specific, or mosaic, evolution. Regardless, the respective advantages of developmentally coupled and uncoupled brain architectures mean that both may persist in fluctuating environments. This implies that developmental coupling is unlikely to be a persistent constraint, but could evolve as an adaptive outcome to selection to maintain functional integration.
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DOI：
10.1159/000345940
发表时间：
2013
期刊：
Brain, behavior and evolution
影响因子：
--
作者：
Charvet CJ;Darlington RB;Finlay BL
通讯作者：
Finlay BL
影响因子：
0.6
作者：
Currie, Adrian
通讯作者：
Currie, Adrian
影响因子：
9.2
作者：
Barton, Robert A.;Venditti, Chris
通讯作者：
Venditti, Chris
DOI：
10.1098/rstb.1995.0076
发表时间：
1995-06-29
期刊：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
BARTON, RA;PURVIS, A;HARVEY, PH
通讯作者：
HARVEY, PH
影响因子：
2.4
作者：
Barton, RA
通讯作者：
Barton, RA