NCBI Reference Sequences: current status, policy and new initiatives.

NCBI Reference Sequences: current status, policy and new initiatives.
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DOI:
10.1093/nar/gkn721
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发表时间:
2009-01
影响因子:
14.9
通讯作者:
Maglott DR
Maglott DR
中科院分区:
生物学2区
文献类型:
--
作者:
Pruitt KD;Tatusova T;Klimke W;Maglott DR

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NCBI的参考序列(RefSeq)数据库(http://www.ncbi.nlm.nih.gov/RefSeq/)是代表基因组、转录物和蛋白质的序列的策展的非冗余集合。RefSeq记录整合了来自多个来源的信息,并代表了序列、基因和序列特征的当前描述。该数据库包括超过5300种生物,涵盖原核生物、真核生物和病毒,记录了超过5.5 × 106种蛋白质(RefSeq release 30)。特征注释通过策展、协作、从其他源传播和计算的组合来应用。我们在这里报告的数据库,最近的变化,功能注释和记录类型的真核生物(主要是脊椎动物)物种和政策有关的物种包括和基因组注释的最近增长。此外,我们还介绍了RefSeqGene,这是一项支持在稳定的基因组坐标系上报告变异数据的新举措。
NCBI's Reference Sequence (RefSeq) database (http://www.ncbi.nlm.nih.gov/RefSeq/) is a curated non-redundant collection of sequences representing genomes, transcripts and proteins. RefSeq records integrate information from multiple sources and represent a current description of the sequence, the gene and sequence features. The database includes over 5300 organisms spanning prokaryotes, eukaryotes and viruses, with records for more than 5.5 × 106 proteins (RefSeq release 30). Feature annotation is applied by a combination of curation, collaboration, propagation from other sources and computation. We report here on the recent growth of the database, recent changes to feature annotations and record types for eukaryotic (primarily vertebrate) species and policies regarding species inclusion and genome annotation. In addition, we introduce RefSeqGene, a new initiative to support reporting variation data on a stable genomic coordinate system.
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