Disabled-2 Determines Commitment of a Pre-adipocyte Population in Juvenile Mice.
Disabled-2 Determines Commitment of a Pre-adipocyte Population in Juvenile Mice.
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Disabled-2 确定幼年小鼠前脂肪细胞群的承诺。
DOI：
10.1038/srep35947
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发表时间：
2016
影响因子：
4.6
通讯作者：
Xu,Xiang-Xi
中科院分区：
文献类型：
--
作者：
Tao,Wensi;Moore,Robert;Meng,Yue;Yeasky,ToniM;Smith,ElizabethR;Xu,Xiang-Xi
Disabled-2 (Dab2) is a widely expressed clathrin binding endocytic adaptor protein and known for the endocytosis of the low-density lipoprotein (LDL) family receptors. Dab2 also modulates endosomal Ras/MAPK (Erk1/2) activity by regulating the disassembly of Grb2/Sos1 complexes associated with clathrin-coated vesicles. We found that the most prominent phenotype of Dab2 knockout mice was their striking lean body composition under a high fat and high caloric diet, although the weight of the mutant mice was indistinguishable from wild-type littermates on a regular chow. The remarkable difference in resistance to high caloric diet-induced weight gain of thedab2-deleted mice was presented only in juvenile but not in mature mice. Investigation using Dab2-deficient embryonic fibroblasts and mesenchymal stromal cells indicated that Dab2 promoted adipogenic differentiation by modulation of MAPK (Erk1/2) activity, which otherwise suppresses adipogenesis through the phosphorylation of PPARγ. The results suggest that Dab2 is required for the excessive calorie-induced differentiation of an adipocyte progenitor cell population that is present in juvenile but depleted in mature animals. The finding provides evidence for a limited pre-adipocyte population in juvenile mammals and the requirement of Dab2 in the regulation of Ras/MAPK signal in the commitment of the precursor cells to adipose tissues.
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影响因子：
56.9
作者：
J. Waldman;J. W. Munger;D. Jacob;R. Flagan;J. J. Morgan-J.;M. Hoffmann
通讯作者：
J. Waldman;J. W. Munger;D. Jacob;R. Flagan;J. J. Morgan-J.;M. Hoffmann
空气污染物对人体健康影响的实验研究：一、设计考虑。
DOI：
--
发表时间：
1975
期刊：
Archives of Environmental Health An International Journal
影响因子：
--
作者：
J. D. Hackney;William S. Linn;Ramon D. Buckley;E. Pedersen;Sarunas K. Karuza;D. Law;D. Armin Fischer
通讯作者：
D. Armin Fischer
酸性气溶胶对健康影响的背景。
影响因子：
10.4
作者：
M. Lippmann
通讯作者：
M. Lippmann
吸入硫酸对青少年哮喘患者肺功能的影响。
DOI：
10.1164/arrd.1983.128.2.221
发表时间：
1983
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Koenig,JQ;Pierson,WE;Horike,M
通讯作者：
Horike,M
暴露于亚微米尺寸范围硫酸气溶胶的正常和哮喘志愿者的呼吸剂量反应研究
影响因子：
1.9
作者：
E. Avol;W. Linn;J. Whynot;K. R. Anderson;D. A. Shamoo;L. M. Valencia;David E. Little;J. D. Hackney
通讯作者：
J. D. Hackney