Direct observation of morphological transformation from twisted ribbons into helical ribbons.
Direct observation of morphological transformation from twisted ribbons into helical ribbons.
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DOI：
10.1021/ja100613w
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发表时间：
2010-07-07
影响因子：
15
通讯作者：
Stupp SI
中科院分区：
文献类型：
--
作者：
Pashuck ET;Stupp SI
我们报道了在多肽两亲分子的超分子组装中直接观察到从扭曲带到螺旋带的纳米结构转变。用低温电子显微镜发现，含有芳香族残基的两亲肽分子首先在几秒的时间范围内组装成短的扭曲带，然后在几分钟的时间尺度上拉长，最后在几周的过程中转变为螺旋带。通过合成没有芳香族侧基的类似分子，发现在同一时间段内形成了不经历任何转变的圆柱形纳米结构。对多肽聚集亚稳态的研究有助于我们理解淀粉样蛋白相关疾病，如阿尔茨海默氏症。
We report on the direct observation of a nanostructural transformation from a twisted ribbon to a helical ribbon in supramolecular assemblies of peptide amphiphiles. Using cryogenic electron microscopy, a peptide amphiphile molecule containing aromatic residues was found to first assemble into short twisted ribbons in the time range of seconds, which then elongate in the time scale of minutes, and finally transform into helical ribbons over the course of weeks. By synthesizing an analogous molecule without the aromatic side groups, it was found that a cylindrical nanostructure is formed that does not undergo any transitions during the same time period. The study of metastable states in peptide aggregation can contribute to our understanding of amyloid-related diseases such as Alzheimer’s.
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影响因子：
64.8
作者：
Aggeli, A;Bell, M;Radford, SE
通讯作者：
Radford, SE
影响因子：
15
作者：
Muraoka, Takahiro;Cui, Honggang;Stupp, Samuel I.
通讯作者：
Stupp, Samuel I.
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5.6
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56.9
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通讯作者：
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15
作者：
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通讯作者：
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