Moderate traumatic brain injury causes acute dendritic and synaptic degeneration in the hippocampal dentate gyrus.
Moderate traumatic brain injury causes acute dendritic and synaptic degeneration in the hippocampal dentate gyrus.
复制标题
DOI：
10.1371/journal.pone.0024566
复制
发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Gao X;Deng P;Xu ZC;Chen J
Hippocampal injury-associated learning and memory deficits are frequent hallmarks of brain trauma and are the most enduring and devastating consequences following traumatic brain injury (TBI). Several reports, including our recent paper, showed that TBI brought on by a moderate level of controlled cortical impact (CCI) induces immature newborn neuron death in the hippocampal dentate gyrus. In contrast, the majority of mature neurons are spared. Less research has been focused on these spared neurons, which may also be injured or compromised by TBI. Here we examined the dendrite morphologies, dendritic spines, and synaptic structures using a genetic approach in combination with immunohistochemistry and Golgi staining. We found that although most of the mature granular neurons were spared following TBI at a moderate level of impact, they exhibited dramatic dendritic beading and fragmentation, decreased number of dendritic branches, and a lower density of dendritic spines, particularly the mushroom-shaped mature spines. Further studies showed that the density of synapses in the molecular layer of the hippocampal dentate gyrus was significantly reduced. The electrophysiological activity of neurons was impaired as well. These results indicate that TBI not only induces cell death in immature granular neurons, it also causes significant dendritic and synaptic degeneration in pathohistology. TBI also impairs the function of the spared mature granular neurons in the hippocampal dentate gyrus. These observations point to a potential anatomic substrate to explain, in part, the development of posttraumatic memory deficits. They also indicate that dendritic damage in the hippocampal dentate gyrus may serve as a therapeutic target following TBI.
登录
查看更多内容
影响因子：
3.3
作者：
Hoskison MM;Moore AN;Hu B;Orsi S;Kobori N;Dash PK
通讯作者：
Dash PK
影响因子：
9.9
作者：
Isoniemi, H.;Kurki, T.;Portin, R.
通讯作者：
Portin, R.
影响因子：
2.5
作者：
FELDMAN, ML;PETERS, A
通讯作者：
PETERS, A
影响因子：
2.9
作者：
Hellmich, HL;Capra, B;Prough, DS
通讯作者：
Prough, DS
影响因子：
4.2
作者：
Gao, Xiang;Deng-Bryant, Ying;Cho, Wongil;Carrico, Kimberly M.;Hall, Edward D.;Chen, Jinhui
通讯作者：
Chen, Jinhui