Impact of the gut microbiome on mucosal inflammation.

Impact of the gut microbiome on mucosal inflammation.
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DOI:
10.1016/j.it.2013.07.001
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发表时间:
2013-09
影响因子:
16.8
通讯作者:
Strober W
Strober W
中科院分区:
医学1区
文献类型:
--
作者:
Strober W

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在过去的10年里,越来越明显的是,肠道微生物群对它所并存的免疫系统--粘膜免疫系统--有深远的影响。在这里,我探讨了最近的研究,在这些研究中,微生物区系的作用扩大或促进了抗炎或调节免疫机制,或有利于在该系统中发展促炎免疫机制。然后,我将重点放在炎症性肠病中这些相反的过程是如何发挥作用的,炎症性肠病是一种正常的免疫动态平衡被扰乱、炎症根深蒂固的疾病。
In the last 10 years it has become increasingly apparent that the gut microbiome has profound effects on the immune system to which it is juxtaposed, the mucosal immune system. Here I explore recent studies in which the effects of the microbiota expand or facilitate anti-inflammatory or regulatory immunologic machinery or which favor development of pro-inflammatory immunologic machinery in this system. I then focus on how these opposing processes play out in inflammatory bowel disease, a disease in which normal immune homeostasis is disturbed and inflammation takes hold.
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