Cellular Basis of Morphogenetic Change: Looking Back after 30 Years of Progress on Developmental Signaling Pathways
Cellular Basis of Morphogenetic Change: Looking Back after 30 Years of Progress on Developmental Signaling Pathways
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形态发生变化的细胞基础：发育信号通路 30 年进展回顾
DOI：
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
J. Gerhart
中科院分区：
文献类型：
--
作者：
J. Gerhart
1981年的“形态发生变化的细胞基础”会议讨论了位置信息和细胞解释的模式形成，作为选择基因表达的发育单位的多克隆区室，细胞的形态发生活动，保守的细胞类型，以及新收集的果蝇突变体揭示的发育途径。所有这些都为未来几十年在理解细胞-细胞信号传导和转录调控方面的模式形成以及发育进化方面的巨大进步做出了贡献和准备。本文以脊椎动物胚胎中的Bmp和Wnt信号通路为例，对这些进展进行了总结，这些信号通路介导了胚胎的背腹轴和前后轴的大规模模式。摘要涵盖了接收信号时在两种途径中激活的不同转导成分和转录因子，以及细胞在特定细胞群上产生信号梯度分布的复杂但稳健和适应性的方法。在原肠-神经期这些分布的关键是Spemann的组织者，一个早期胚胎的信号传导和形态发生中心，产生Bmp和Wnt拮抗剂。这些通路本身可以追溯到最早的后生动物，它们在胚胎轴上的应用至少可以追溯到两侧动物的共同祖先。发育的进化涉及到这些途径重复使用的时间和地点的变化，涉及到它们所针对的基因（改变细胞能力）的变化，以及信号分布的方式和位置的变化。
The 1981 session on the Cellular Basis of Morphogenetic Change included discussions of pattern formation by positional information and cellular interpretation, polyclonal compartments as developmental units of selector gene expression, morphogenetic activities of cells, conserved cell types, and the developmental pathways revealed by newly collected Drosophila mutants. All of this was contributory to and preparatory for the great advances of the next decades in the understanding of pattern formation in terms of cell-cell signaling and transcriptional regulation, and in the evolution of development. The present article is a summary of some of these advances, taking the Bmp and Wnt signaling pathways in vertebrate embryos, which mediate the large scale patterning of the dorsoventral and anteroposterior axes of the embryo. The summary covers the different transduction components and transcription factors activated within the two pathways when signals are received, and the complex yet robust and adaptable means by which cells generate graded distributions of signals over specific cell groups. Key to these distributions at the gastrula-neurula stages is Spemann’s organizer, a signaling and morphogenetic center of the early embryo that produces Bmp and Wnt antagonists. The pathways themselves date back to the earliest metazoa, and their use in patterning the embryonic axes dates back at least to the bilaterian common ancestor. The evolution of development has involved changes in the times and places of repeated usage of these pathways, in the genes targeted by them (changing cell competence), and in the means and location of signal distribution.
非洲爪蟾原肠胚自我调节形态发生梯度的系统生物学。
影响因子：
7.2
作者：
Plouhinec,Jean-Louis;DeRobertis,EM
通讯作者：
DeRobertis,EM
DOI：
10.1073/pnas.81.13.4115
发表时间：
1984-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
SCOTT, MP;WEINER, AJ
通讯作者：
WEINER, AJ
DOI：
10.1073/pnas.0601257103
发表时间：
2006-07-25
影响因子：
11.1
作者：
Matus, David Q.;Pang, Kevin;Martindale, Mark Q.
通讯作者：
Martindale, Mark Q.