Mitochondrial Dynamics: A Key Role in Neurodegeneration and a Potential Target for Neurodegenerative Disease.
Mitochondrial Dynamics: A Key Role in Neurodegeneration and a Potential Target for Neurodegenerative Disease.
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线粒体动力学：神经退行性疾病中的关键作用和神经退行性疾病的潜在目标。
DOI：
10.3389/fnins.2021.654785
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发表时间：
2021
影响因子：
4.3
通讯作者：
Hua F
中科院分区：
文献类型：
--
作者：
Yang D;Ying J;Wang X;Zhao T;Yoon S;Fang Y;Zheng Q;Liu X;Yu W;Hua F
在神经退行性疾病中，神经退行性疾病与几种线粒体动力学失衡有关，例如线粒体过度碎片化、线粒体自噬受损和轴突中线粒体线粒体转运受阻。线粒体是一种动态的细胞器，对能量转换、神经元存活和细胞死亡至关重要。由于线粒体动力学对稳态有显着影响，本文主要讨论线粒体动力学在几种神经退行性疾病中的作用。有证据表明，几种线粒体动力学相关蛋白以及相关途径在神经退行性疾病的病理过程中发挥作用，对线粒体功能和代谢产生影响。然而，具体的病理机制需要更好地理解，以提出新的治疗策略，针对线粒体动力学，在最近的研究中显示出希望。
In neurodegenerative diseases, neurodegeneration has been related to several mitochondrial dynamics imbalances such as excessive fragmentation of mitochondria, impaired mitophagy, and blocked mitochondria mitochondrial transport in axons. Mitochondria are dynamic organelles, and essential for energy conversion, neuron survival, and cell death. As mitochondrial dynamics have a significant influence on homeostasis, in this review, we mainly discuss the role of mitochondrial dynamics in several neurodegenerative diseases. There is evidence that several mitochondrial dynamics-associated proteins, as well as related pathways, have roles in the pathological process of neurodegenerative diseases with an impact on mitochondrial functions and metabolism. However, specific pathological mechanisms need to be better understood in order to propose new therapeutic strategies targeting mitochondrial dynamics that have shown promise in recent studies.
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通讯作者：
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