Is heart disease a risk factor for low dementia test battery scores in older persons with Down syndrome? Exploratory, pilot study, and commentary.
Is heart disease a risk factor for low dementia test battery scores in older persons with Down syndrome? Exploratory, pilot study, and commentary.
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DOI：
10.1080/20473869.2017.1301023
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发表时间：
2020
影响因子：
2.1
通讯作者：
Lukiw WJ
中科院分区：
文献类型：
--
作者：
Percy ME;Lukiw WJ
某些心脏疾病和疾病在唐氏综合征（DS; 21三体）中很常见，但它们在DS老年人中普遍存在的早发性痴呆中的作用尚未得到评估。为了解决这一知识缺口，我们进行了一项研究，研究了使用已发表的痴呆测试组合（DTB）获得的低神经认知/行为评分的风险因素。参与者为居住在纽约的DS成人（N = 29;平均年龄46岁）。我们问了三个问题。1.患有任何类型的心脏病是否会影响DTB评分与实际年龄之间的关联？2.甲状腺状态是否影响心脏病和DTB评分之间的关联？3.载脂蛋白E（APOE）的E4或E2等位基因与DTB评分或心脏病相关吗？本研究为回顾性、先导性和探索性研究。它涉及分析先前为DS老化研究建立的数据库中的信息。参与者平均有中度智力残疾。每个人的信息包括：性别，年龄，通过合并DTB各个子量表的结果获得的单一DTB评分，有无心脏病，甲状腺状态（治疗的甲状腺功能减退症或正常）和APOE基因型。通过检查图表和列联表，使趋势可视化。用于评估相关性的统计方法包括Pearson相关分析、Fisher精确检验（双尾）和比值比分析。在95%置信水平下解释P值，无需Bonferroni校正。P值> 0.05 <.1 were considered trends. The negative correlation between DTB scores and age was significant in those with heart disease but not in those without. Heart disease was significantly associated with DTB scores >1 SD，低于样本平均值;在接受治疗的甲状腺功能减退症患者中，心脏病与低DTB评分之间存在强相关性，但在甲状腺状态正常的患者中则无相关性。在男性中，APOE基因型与心脏病弱相关（E4，易患; E2，保护性）。基于本研究的潜在重要发现，需要进行大型前瞻性研究来确认和扩展观察结果。在这些情况下，应记录个体的特定心脏状况或疾病以及其他医学合并症。
Certain heart conditions and diseases are common in Down syndrome (DS; trisomy 21), but their role in early onset dementia that is prevalent in older adults with DS has not been evaluated. To address this knowledge gap, we conducted a study of risk factors for low neurocognitive/behavioral scores obtained with a published dementia test battery (DTB). Participants were adults with DS living in New York (N = 29; average age 46 years). We asked three questions. 1. Does having any type of heart disease affect the association between DTB scores and chronological age? 2. Does thyroid status affect the association between heart disease and DTB scores? 3. Are the E4 or E2 alleles of apolipoprotein E (APOE) associated with DTB scores or with heart disease? The study was retrospective, pilot, and exploratory. It involved analysis of information in a database previously established for the study of aging in DS. Participants had moderate intellectual disability on average. Information for each person included: gender, age, a single DTB score obtained by combining results from individual subscales of the DTB, the presence or absence of heart disease, thyroid status (treated hypothyroidism or normal), and APOE genotype. Trends were visualized by inspection of graphs and contingency tables. Statistical methods used to evaluate associations included Pearson correlation analysis, Fisher’s exact tests (2-tailed), and odds ratio analysis. P values were interpreted at the 95% confidence level without Bonferroni correction. P values >.05<.1 were considered trends. The negative correlation between DTB scores and age was significant in those with heart disease but not in those without. Heart disease was significantly associated with DTB scores >1 SD below the sample mean; there was a strong association between heart disease and low DTB scores in those with treated hypothyroidism but not in those with normal thyroid status. The APOE genotype was weakly associated with heart disease (E4, predisposing; E2, protective) in males. On the basis of the potentially important findings from the present study, large prospective studies are warranted to confirm and extend the observations. In these, particular heart conditions or diseases and other medical comorbidities in individuals should be documented.
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影响因子：
24
作者：
Anand SS;Hawkes C;de Souza RJ;Mente A;Dehghan M;Nugent R;Zulyniak MA;Weis T;Bernstein AM;Krauss RM;Kromhout D;Jenkins DJA;Malik V;Martinez-Gonzalez MA;Mozaffarian D;Yusuf S;Willett WC;Popkin BM
通讯作者：
Popkin BM
影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
影响因子：
4.8
作者：
Bhattacharjee S;Zhao Y;Hill JM;Percy ME;Lukiw WJ
通讯作者：
Lukiw WJ
DOI：
10.3233/jad-2011-0010
发表时间：
2011
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Austin BP;Nair VA;Meier TB;Xu G;Rowley HA;Carlsson CM;Johnson SC;Prabhakaran V
通讯作者：
Prabhakaran V
影响因子：
9.9
作者：
Barnes, Deborah E.;Kaup, Allison;Yaffe, Kristine
通讯作者：
Yaffe, Kristine