Interrelationship between prostaglandins and renin release.
Interrelationship between prostaglandins and renin release.
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前列腺素和肾素释放之间的相互关系。
DOI：
10.1038/ki.1981.85
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发表时间：
1981
影响因子：
19.6
通讯作者：
Nies,AS
中科院分区：
文献类型：
--
作者：
Gerber,JG;Olson,RD;Nies,AS
Strong 等人首次提出前列腺素 (PG) 可能参与肾素释放，他们报告称，患有肾血管性高血压的女性的缺血半个肾脏中肾素和 PG 含量大幅增加。尽管我们现在知道组织中的PG含量没有意义，因为与肾素不同，PG不储存在组织中，但Strong等人的观察确实促使研究人员研究PG对肾素释放的影响。Vander是第一个检查PGE2和PGE1对肾素释放的影响的人，但发现这些PG在狗体内是不活跃的[21。他的结论是 PG 可以参与肾脏生理学，但可能不参与肾素的释放。随着Vane的重要发现，即非甾体抗炎药抑制PG合成[3]，可以采用另一种方法来检查PG对肾素释放的参与。事实上，吲哚美辛被发现可以降低狗、兔子和人的血浆肾素活性[4-6]。吲哚美辛对肾素释放的这种作用起效很快，并且不受盐摄入量的影响[71。结构上不同的非甾体抗炎药也会降低血浆肾素活性，这一事实进一步证实了 PG 可能在肾素释放中发挥重要作用的观点。证实 PG 和肾素释放之间相互关系的进一步证据是，将花生四烯酸（“2”系列 PG 的前体）输注到兔、大鼠和狗的肾动脉或下主动脉中，导致血浆肾素活性增加 [5,8,9]。此外，当花生四烯酸与兔肾皮质切片一起孵育时，导致肾素释放到介质中。花生四烯酸的这种作用
The first suggestion that prostaglandins (PG's) may participate in the release of renin came from Strong et al, who reported a large increase in renin and PG contents in the ischemic half of a kidney from a woman with renovascular hypertension [Ii. Although we now know that tissue PG content is not meaningful because PG's, unlike renin, are not stored in tissues, the observation by Strong et al did prompt researchers to look at the effect of PG's on renin release.Vander was the first to examine the effect of PGE2 and PGE1 on renin release, but found that these PG's were inactive in the dog [21. His conclu-sions were that PG's could participate in renal physiology, but probably not in the release of renin. With the important discovery by Vane, that nonsteroidal antiinflammatory drugs inhibit PG synthesis [3], another approach could be taken to examine the participation of PG's on renin release. Indeed, indomethacin was found to lower plasma renin activity in the dog, rabbit, and man [4—6]. This effect of indomethacin on renin release was quick in onset and unaffected by salt intake [71. The fact that structurally dissimilar nonsteroidal antiinflamma-tory drugs also lowered plasma renin activity added credence to the idea that PG's may play an important role in the release of renin. Further evidence solidifying the interrelationship between PG's and renin release was the demonstration that the infusion of arachidonic acid (precursor of the PG's of the" 2" series) into the renal artery or the lower aorta in the rabbit, rat, and dog resulted in an increase in the plasma renin activity [5, 8, 9]. In addition, arachidonic acid, when incubated with rabbit renal cortical slices caused the release of renin into the media. This effect of arachidonic acid
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花生四烯酸增加，吲哚美辛降低兔血浆肾素活性。
影响因子：
5
作者：
C. Larsson;P. Weber;E. Änggård
通讯作者：
E. Änggård
前列腺素介导的肾皮质切片中的肾素释放。
DOI：
--
发表时间：
1980
期刊：
Advances in prostaglandin and thromboxane research
影响因子：
--
作者：
A. Whorton;J. Lazar;M. Smigel;J. Oates
通讯作者：
J. Oates
影响因子：
--
作者：
BLAINE, EH;DAVIS, JO;PREWITT, RL
通讯作者：
PREWITT, RL
吲哚美辛对人血浆肾素活性的抑制
影响因子：
20.1
作者：
Ürgen C. FrÖlich;J. Hollifield;J. C. Dormois;Brigitte L. FrOlich;Hanns örg Seyberth;A. Michelakis;J. Oates
通讯作者：
J. Oates
前列腺素内过氧化物类似物对犬肾功能、血流动力学和肾素释放的影响。
影响因子：
5
作者：
J. Gerber;E. Ellis;J. Hollified;A. Nies
通讯作者：
A. Nies