Dizocilpine infusion has a different effect in the development of morphine and cocaine sensitization: behavioral and neurochemical aspects
Dizocilpine infusion has a different effect in the development of morphine and cocaine sensitization: behavioral and neurochemical aspects
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地佐环平输注对吗啡和可卡因致敏的发展具有不同的作用：行为和神经化学方面
DOI：
10.1016/s0306-4522(01)00483-3
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发表时间：
2002
期刊：
影响因子：
3.3
通讯作者：
M. G. Montis
中科院分区：
文献类型：
--
作者：
S. Scheggi;S. Mangiavacchi;F. Masi;C. Gambarana;A. Tagliamonte;M. G. Montis
The stimulation of glutamate receptors plays a relevant role in the development of behavioral sensitization to psychostimulants, while less clear results have been obtained on their role in morphine sensitization. We addressed this issue by comparing the development of cocaine and morphine sensitization under a continuous s.c. infusion of the N-methyl-D-aspartate (NMDA) antagonist dizocilpine (0.1 mg/kg/24 h). Moreover, we studied the expression of NMDA and α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptor subunits in discrete limbic areas of rats sensitized to morphine or cocaine with or without the concomitant dizocilpine infusion. It was observed that dizocilpine infusion did not prevent the development of morphine sensitization, while it prevented the development of tolerance to morphine-induced analgesia. Finally, morphine-sensitized animals did not present any modification in the subunit expression of glutamate receptors in the brain areas examined. In agreement with previous results, we found that dizocilpine infusion prevented the development of cocaine sensitization. Moreover, we observed that rats sensitized to cocaine presented a significant increase in the levels of GLUR1, NR1 and NR2B, in the nucleus accumbens, and of NR2B in the hippocampus compared to control animals. Such modifications were absent in rats administered cocaine under dizocilpine infusion. We conclude that: (i) morphine sensitization is a neuroadaptive phenomenon which does not appear to require NMDA receptor activity in order to develop; (ii) cocaine sensitization is clearly dependent on NMDA receptor activity, as dizocilpine infusion prevented the occurrence of glutamate receptors modifications as well as the development of sensitization.
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影响因子：
56.9
作者：
TRUJILLO, KA;AKIL, H
通讯作者：
AKIL, H
DOI：
--
发表时间：
1993-03
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
P. Tiseo;C. Inturrisi
通讯作者：
P. Tiseo;C. Inturrisi
地佐西平 (MK-801) 会阻断大鼠对镇痛药的耐受性，但不会阻断吗啡的热效应。
影响因子：
3.1
作者：
Bhargava,HN;Matwyshyn,GA
通讯作者：
Matwyshyn,GA
影响因子：
56.9
作者：
Shi, SH;Hayashi, Y;Malinow, R
通讯作者：
Malinow, R