Brain-derived neurotrophic factor and addiction: Pathological versus therapeutic effects on drug seeking.
Brain-derived neurotrophic factor and addiction: Pathological versus therapeutic effects on drug seeking.
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DOI：
10.1016/j.brainres.2014.10.058
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发表时间：
2015-12-02
期刊：
影响因子：
2.9
通讯作者：
Peters, Jamie
中科院分区：
文献类型：
--
作者：
Barker, Jacqueline M.;Taylor, Jane R.;De Vries, Taco J.;Peters, Jamie
关键词：
许多滥用药物会导致导致成瘾行为的神经回路中内源性脑源性神经营养因子（BDNF）表达发生变化。 BDNF 是记忆巩固过程中已知的分子介质，在行为和神经生理学水平上都很明显。特定的神经回路负责存储和执行获取药物的运动程序，而其他神经回路则负责主动抑制这些“寻找”系统。这些寻找回路是随着药物相关线索与其引发的条件反应之间形成关联而建立的。这种条件反应（例如药物寻求）可以通过被动削弱寻求回路或通过灭绝主动抑制这些回路来减少。当线索和药物之间的关联被破坏时，例如在没有药物存在的情况下暴露线索，就会发生消退学习。提示暴露疗法已被提议作为治疗成瘾的一种治疗途径。在这里，我们探讨了 BDNF 在消退回路中的作用，并与在长时间退出期间“孵化”的寻找回路进行比较。我们首先讨论 BDNF 在恐惧和可卡因寻求行为的消退记忆中的作用，其中消退回路在边缘下前额叶皮层 (PFC) 中重叠。我们强调雌激素在海马-前额叶回路中促进 BDNF 样作用的能力，并考虑性别差异在寻求药物行为的消失和孵化中的作用。最后，我们研究阿片类药物和酒精如何在消退回路中的 BDNF 功能方面“打破常规”。
Many abused drugs lead to changes in endogenous brain-derived neurotrophic factor (BDNF) expression in neural circuits responsible for addictive behaviors. BDNF is a known molecular mediator of memory consolidation processes, evident at both behavioral and neurophysiological levels. Specific neural circuits are responsible for storing and executing drug-procuring motor programs, whereas other neural circuits are responsible for the active suppression of these “seeking” systems. These seeking-circuits are established as associations are formed between drug-associated cues and the conditioned responses they elicit. Such conditioned responses (e.g. drug seeking) can be diminished either through a passive weakening of seeking-circuits or an active suppression of those circuits through extinction. Extinction learning occurs when the association between cues and drug are violated, for example, by cue exposure without the drug present. Cue exposure therapy has been proposed as a therapeutic avenue for the treatment of addictions. Here we explore the role of BDNF in extinction circuits, compared to seeking-circuits that “incubate” over prolonged withdrawal periods. We begin by discussing the role of BDNF in extinction memory for fear and cocaine-seeking behaviors, where extinction circuits overlap in infralimbic prefrontal cortex (PFC). We highlight the ability of estrogen to promote BDNF-like effects in hippocampal–prefrontal circuits and consider the role of sex differences in extinction and incubation of drug-seeking behaviors. Finally, we examine how opiates and alcohol “break the mold” in terms of BDNF function in extinction circuits.
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影响因子：
25
作者：
Bossert, Jennifer M.;Stern, Anna L.;Theberge, Florence R. M.;Cifani, Carlo;Koya, Eisuke;Hope, Bruce T.;Shaham, Yavin
通讯作者：
Shaham, Yavin
影响因子：
3.5
作者：
Chang, Yao-Ju;Yang, Chih-Hao;Hsu, Kuei-Sen
通讯作者：
Hsu, Kuei-Sen
DOI：
10.1523/jneurosci.0005-12.2012
发表时间：
2012-04-04
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bossert JM;Stern AL;Theberge FR;Marchant NJ;Wang HL;Morales M;Shaham Y
通讯作者：
Shaham Y
影响因子：
3.5
作者：
Cabezas, Carolina;Buno, Washington
通讯作者：
Buno, Washington
影响因子：
3.8
作者：
Bobzean, Samara A. Morris;Dennis, Torry S.;Perrotti, Linda I.
通讯作者：
Perrotti, Linda I.