Association between homocysteine level and the risk of diabetic retinopathy: a systematic review and meta-analysis.
Association between homocysteine level and the risk of diabetic retinopathy: a systematic review and meta-analysis.
复制标题
DOI：
10.1186/s13098-018-0362-1
复制
发表时间：
2018
影响因子：
4.8
通讯作者：
Yang K
中科院分区：
文献类型：
--
作者：
Lei X;Zeng G;Zhang Y;Li Q;Zhang J;Bai Z;Yang K
既往研究表明，高同型半胱氨酸（Hcy）水平是大血管疾病的独立危险因素。然而，高同型半胱氨酸血症与糖尿病视网膜病变进展之间的关系仍然存在争议。因此，本系统综述和荟萃分析的目的是探讨Hcy与糖尿病视网膜病变风险之间的任何潜在关联。检索PubMed、Embase和Cochrane图书馆数据库，筛选从数据库建立之日至2017年11月符合纳入标准的研究。采用综合优势比（OR）和95%置信区间（CIs）计算Hcy与糖尿病视网膜病变风险之间关系的综合效应估计。敏感性、亚组分析和发表偏倚也进行了评估。荟萃分析纳入了11项研究，共涉及2184名糖尿病患者。总结OR提示糖尿病患者Hcy水平升高与糖尿病视网膜病变风险增加相关（OR 1.62; 95% CI 1.29-2.03; p < 0.001）。虽然在纳入的研究中发现了显著的异质性，但敏感性分析的结果仍然具有统计学意义。亚组分析发现，在大多数亚组中，Hcy与糖尿病视网膜病变之间存在显著相关性，但如果样本量< 100，受试者患有1型糖尿病，且研究质量较低，则未发现显著相关性。本研究结果表明，Hcy水平升高与糖尿病视网膜病变的风险增加有关，特别是在2型糖尿病患者中。这一发现可能有助于糖尿病患者获得有效的管理策略，以防止糖尿病视网膜病变的进展。本文的在线版本（10.1186/s13098-018-0362-1）包含补充资料，仅供授权用户使用。
Previous studies have demonstrated that elevated homocysteine (Hcy) level represents an independent risk factor for macrovascular disease. However, the relationship between hyperhomocysteinemia and the progression of diabetic retinopathy in patients remains controversial. Hence, the purpose of this systematic review and meta-analysis was to explore any potential association between Hcy and the risk of diabetic retinopathy. PubMed, Embase, and the Cochrane Library databases were searched to screen studies that fulfilled the inclusion criteria from date of database inception to November 2017. The summary odds ratio (OR) with 95% confidence intervals (CIs) was used to calculate the pooled effect estimate for the relationship between Hcy and diabetic retinopathy risk. Sensitivity, subgroup analyses, and publication bias were also assessed. Eleven studies involving a total of 2184 diabetic patients were included in the meta-analysis. The summary OR suggested that increased Hcy level in diabetic patients was associated with an increased risk of diabetic retinopathy (OR 1.62; 95% CI 1.29–2.03; p < 0.001). Although significant heterogeneity was detected among the included studies, the findings of sensitivity analysis remained statistically significant. Subgroup analyses found a significant association between Hcy and diabetic retinopathy in most subsets, but no significant association was found if the sample size was < 100, participants had type 1 diabetes mellitus, and the study quality was low. The findings of this study suggested that elevated Hcy level was associated with an increased risk of diabetic retinopathy, especially in type 2 diabetic patients. This finding may help diabetic patients to achieve effective management strategy to prevent the progression of diabetic retinopathy. The online version of this article (10.1186/s13098-018-0362-1) contains supplementary material, which is available to authorized users.
登录
查看更多内容
DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
3.7
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
3
作者：
de Luis, DA;Fernandez, N;Romero, E
通讯作者：
Romero, E
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
3.8
作者：
Abdella, NA;Mojiminiyi, OA;Moussa, MA
通讯作者：
Moussa, MA