Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease.
Phenotypic regional functional imaging patterns during memory encoding in mild cognitive impairment and Alzheimer's disease.
复制标题
DOI：
10.1016/j.jalz.2011.12.006
复制
发表时间：
2013-05
期刊：
影响因子：
--
通讯作者：
Welsh-Bohmer KA
中科院分区：
文献类型：
--
作者：
Browndyke JN;Giovanello K;Petrella J;Hayden K;Chiba-Falek O;Tucker KA;Burke JR;Welsh-Bohmer KA
阿尔茨海默病 (AD) 或轻度认知障碍 (MCI) 的可靠血氧水平依赖性 (BOLD) fMRI 表型生物标志物可能只能通过对功能神经影像研究文献进行系统、定量和综合检查才能得出。对 AD 和 MCI 样本中相对于正常对照的情景记忆编码操作进行了一系列随机效应、激活似然估计 (ALE) 荟萃分析。 ALE 分析基于对截至 2010 年 1 月发表的所有基于任务的 AD 和 MCI 功能神经影像研究的彻底文献检索。分析涵盖 16 项 fMRI 研究，为 ALE 荟萃分析产生了 144 个不同的焦点。 ALE 结果表明，在总体 BOLD 功能神经影像研究文献中，相对于正常对照，MCI 和 AD 患者存在一些基于区域任务的 BOLD 一致性。与正常对照相比，AD 患者和显着风险 (MCI) 患者在内侧颞叶 (MTL) 的情景记忆编码过程中表现出统计学上显着的一致性激活差异，特别是海马旁回、额上回、楔前叶和楔叶。 ALE 一致性广泛支持在患病或预期疾病前状况下的情景记忆编码尝试期间存在额叶代偿活动、MTL 活动改变和后中线“默认模式”过度激活。总而言之，这些强大的共性可能构成 AD 中基于任务的功能磁共振成像记忆编码表型的基础。
Reliable blood-oxygen-level-dependent (BOLD) fMRI phenotypic biomarkers of Alzheimer's disease (AD) or mild cognitive impairment (MCI) are likely to emerge only from a systematic, quantitative, and aggregate examination of the functional neuroimaging research literature. A series of random-effects, activation likelihood estimation (ALE) meta-analyses were conducted on studies of episodic memory encoding operations in AD and MCI samples relative to normal controls. ALE analyses were based upon a thorough literature search for all task-based functional neuroimaging studies in AD and MCI published up to January 2010. Analyses covered 16 fMRI studies, which yielded 144 distinct foci for ALE meta-analysis. ALE results indicated several regional task-based BOLD consistencies in MCI and AD patients relative to normal controls across the aggregate BOLD functional neuroimaging research literature. Patients with AD and those at significant risk (MCI) showed statistically significant consistent activation differences during episodic memory encoding in the medial temporal lobe (MTL), specifically parahippocampal gyrus, as well superior frontal gyrus, precuneus, and cuneus, relative to normal controls. ALE consistencies broadly support the presence of frontal compensatory activity, MTL activity alteration, and posterior midline “default mode” hyperactivation during episodic memory encoding attempts in the diseased or prospective pre-disease condition. Taken together these robust commonalities may form the foundation for a task-based fMRI phenotype of memory encoding in AD.
登录
查看更多内容
影响因子：
4.8
作者：
Eickhoff, Simon B.;Laird, Angela R.;Grefkes, Christian;Wang, Ling E.;Zilles, Karl;Fox, Peter T.
通讯作者：
Fox, Peter T.
影响因子：
2.8
作者：
Dickerson BC;Sperling RA
通讯作者：
Sperling RA
影响因子：
2.6
作者：
Ford JH;Verfaellie M;Giovanello KS
通讯作者：
Giovanello KS
影响因子：
17.7
作者：
Callicott, JH;Egan, MF;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T