The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus.
The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus.
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DOI：
10.1111/j.1582-4934.2008.00312.x
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发表时间：
2008-12
影响因子：
5.3
通讯作者：
Renton L
中科院分区：
文献类型：
--
作者：
Ripamonti U;Richter PW;Nilen RW;Renton L
在非人灵长类动物Chacma baboon Papio ursinus中进行了长期研究，以研究双相羟基磷灰石/β-磷酸三钙（HA/β-TCP）仿生基质诱导骨形成的作用。分别以40/60和20/80的预烧结比（wt%）烧结HA/β-TCP仿生基质并植入4只成年狒狒的腹直肌和颅骨缺损中。烧结后相含量比分别为19/81和4/96。在第90天和第365天的形态学分析显示在仿生基质的凹部内显著诱导骨形成，通过植入基质的诱导和再吸收/溶解具有实质性骨形成。在颅骨缺损中植入一年后，4/96双相仿生构建体显示出显著的骨形成诱导，植入支架显著溶解。植入的智能仿生基质诱导从头骨形成，即使在没有外源性应用的转化生长因子-β（TGF-β）超家族的成骨蛋白的情况下。骨形成的诱导仿生灵长类动物皮质-松质骨的重塑周期，由此破骨细胞生成切割的再吸收陷窝、凹坑和凹陷是诱导骨形成的调节剂。HA/β-TCP仿生生物陶瓷中的凹坑具有多功能的自组装能力，可以诱导诱导和促进血管生成和骨形成。驻留的间充质细胞分化成成骨细胞系，其表达、分泌TGF-β超家族的成骨可溶性分子信号并将其嵌入仿生基质的凹部内，引发骨形成作为次级反应。
Long-term studies in the non-human primate Chacma baboon Papio ursinus were set to investigate the induction of bone formation by biphasic hydroxyapatite/p-tricalcium phosphate (HA/β-TCP) biomimetic matrices. HA/β-TCP biomimetic matrices in a pre-sinter ratio (wt%) of 40/60 and 20/80, respectively, were sintered and implanted in the rectus abdominis and in calvarial defects of four adult baboons. The post-sinter phase content ratios were 19/81 and 4/96, respectively. Morphological analyses on day 90 and 365 showed significant induction of bone formation within concavities of the biomimetic matrices with substantial bone formation by induction and resorption/dissolution of the implanted matrices. One year after implantation in calvarial defects, 4/96 biphasic biomimetic constructs showed prominent induction of bone formation with significant dissolution of the implanted scaffolds. The implanted smart biomimetic matrices induce de novo bone formation even in the absence of exogenously applied osteogenic proteins of the transforming growth factor-β(TGF-β) superfamily. The induction of bone formation biomimetizes the remodelling cycle of the cortico-cancellous bone of primates whereby resorption lacunae, pits and concavities cut by osteoclastogenesis are regulators of bone formation by induction. The concavities assembled in HA/β-TCP biomimetic bioceramics are endowed with multifunctional pleiotropic self-assembly capacities initiating and promoting angiogenesis and bone formation by induction. Resident mesenchymal cells differentiate into osteoblastic cell lines expressing, secreting and embedding osteogenic soluble molecular signals of the TGF-β superfamily within the concavities of the biomimetic matrices initiating bone formation as a secondary response.
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影响因子：
1.9
作者：
Boyne, PJ;Lilly, LC;Triplett, RG
通讯作者：
Triplett, RG
影响因子：
14
作者：
Raynaud, S;Champion, E;Thomas, P
通讯作者：
Thomas, P
DOI：
10.1002/jbm.820230806
发表时间：
1989-08-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
DACULSI, G;LEGEROS, RZ;KEREBEL, B
通讯作者：
KEREBEL, B
DOI：
10.2106/00004623-200300003-00014
发表时间：
2003-01-01
影响因子：
5.3
作者：
Einhorn, TA
通讯作者：
Einhorn, TA
影响因子：
14
作者：
Fellah, Borhane H.;Gauthier, Olivier;Layrolle, Pierre
通讯作者：
Layrolle, Pierre