Electroencephalography Source Functional Connectivity Reveals Abnormal High-Frequency Communication Among Large-Scale Functional Networks in Depression.
Electroencephalography Source Functional Connectivity Reveals Abnormal High-Frequency Communication Among Large-Scale Functional Networks in Depression.
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DOI：
10.1016/j.bpsc.2017.07.001
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Whitton AE;Deccy S;Ironside ML;Kumar P;Beltzer M;Pizzagalli DA
Functional magnetic resonance imaging studies of resting-state functional connectivity have shown that major depressive disorder (MDD) is characterized by increased connectivity within the default mode network (DMN) and between the DMN and the fronto-parietal network (FPN). However, much remains unknown about abnormalities in higher frequency (>1 Hz) synchronization. Findings of abnormal synchronization in specific frequencies would contribute to a better understanding of the potential neurophysiological origins of disrupted functional connectivity in MDD. We used the high temporal resolution of electroencephalography (EEG) to compare the spectral properties of resting-state functional connectivity in individuals with MDD (n=65) to healthy controls (n=79), and examined the extent to which connectivity disturbances were evident in a third sample of individuals in remission from depression (rMDD; n=30). Exact Low Resolution Electromagnetic Tomography (eLORETA) was used to compute intra-cortical activity from regions within the DMN and FPN, and functional connectivity was computed using lagged phase synchronization. Compared to controls, the MDD group showed greater within-DMN beta-2 band (18.5–21 Hz) connectivity and greater beta-1 band (12.5–18 Hz) connectivity between the DMN and FPN. This hyperconnectivity was not observed in the rMDD group. However, greater beta-1 band DMN-FPN connectivity was associated with more frequent depressive episodes since first depression onset, even after controlling for current symptom severity. These findings extend our understanding of the neurophysiological basis of abnormal resting-state functional connectivity in MDD and indicate that elevations in high-frequency DMN-FPN connectivity may be a neural marker linked to a more recurrent illness course.
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影响因子：
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