Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity
Bioinspired synthesis of gadolinium-based hybrid nanoparticles as MRI blood pool contrast agents with high relaxivity
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仿生合成钆基杂化纳米颗粒作为具有高弛豫率的 MRI 血池造影剂
DOI：
10.1039/c2jm30629h
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发表时间：
2012-07
影响因子：
--
通讯作者：
Shi, Donglu
中科院分区：
文献类型：
--
作者：
Zhang, Bingbo;Jin, Hantao;Li, Yan;Chen, Bingdi;Liu, Shiyuan;Shi, Donglu
开发了一种独特的生物矿化方法来合成用于有效的血池造影剂的钆基杂化（GH）纳米颗粒。这种方法是生物启发的，对环境无害，而且简单明了。制备的GH纳米粒具有良好的生物相容性，在血清中稳定性良好。它们在水中的纵向弛豫率和横向弛豫率（r1和r2值分别为15.0和19.7 s-1/mM Gd 3+）比Gd-DTPA溶液（r1和r2值分别为3.7和4.6 s-1/mM Gd 3+）高得多。活体小鼠体内T1加权磁共振成像（MRI）显示，GH纳米颗粒的血管内半衰期长达1小时，远长于Gd-DTPA（约10分钟）。由于GH纳米颗粒被发现通过肝胆（HB）处理逐渐清除，因此它们也可以作为肝脏特异性MR造影剂的理想候选物。特别是，这些GH纳米颗粒是生物启发的和环境友好的，因此有希望用于医学成像应用。
A unique biomineralization approach was developed to synthesize gadolinium-based hybrid (GH) nanoparticles for effective blood pool contrast agents. This approach is bioinspired, environmentally benign, and straightforward. As-prepared GH nanoparticles are biocompatible and well stable in serum. They exhibit much higher longitudinal relaxivity and transverse relaxivity in water (r1 and r2 values of 15.0 and 19.7 s−1 per mM of Gd3+, respectively) than those measured for Gd–DTPA solution (r1 and r2 values of 3.7 and 4.6 s−1 per mM of Gd3+, respectively). In vivo T1-weighted magnetic resonance imaging (MRI) in living mice shows that the GH nanoparticles have an intravascular half-life up to 1 h, much longer than that of Gd–DTPA (about 10 min). As the GH nanoparticles were found to be cleared gradually via hepatobiliary (HB) processing, they can also serve as ideal candidates for liver specific MR contrast agents. In particular, these GH nanoparticles are bioinspired and environmentally benign, therefore promising for medical imaging applications.
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影响因子：
--
作者：
J. Wild;J. Woodrow;E. V. van Beek;B. Misselwitz;R. Johnson
通讯作者：
J. Wild;J. Woodrow;E. V. van Beek;B. Misselwitz;R. Johnson
影响因子：
17.1
作者：
Kumar R;Roy I;Ohulchanskky TY;Vathy LA;Bergey EJ;Sajjad M;Prasad PN
通讯作者：
Prasad PN
影响因子：
3.3
作者：
K. Hekimoğlu;Y. Ustundag;A. Duşak;B. Kalaycıoğlu;Halit Beşir;H. Engin;O. Erdem
通讯作者：
K. Hekimoğlu;Y. Ustundag;A. Duşak;B. Kalaycıoğlu;Halit Beşir;H. Engin;O. Erdem
DOI：
10.2217/17435889.3.5.703
发表时间：
2008-10
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Longmire M;Choyke PL;Kobayashi H
通讯作者：
Kobayashi H
DOI：
10.1073/pnas.0707654105
发表时间：
2008-02-05
影响因子：
11.1
作者：
Liu, Zhuang;Davis, Corrine;Dai, Hongjie
通讯作者：
Dai, Hongjie